| 2022 Challenger de Buenos Aires | |
|---|---|
| Date | 26 September – 2 October |
| Edition | 11th |
| Surface | Clay |
| Location | Buenos Aires, Argentina |
| Champions | |
| Singles | |
 Juan Manuel Cerúndolo | |
| Doubles | |
| Guido Andreozzi / Guillermo Durán | |
The 2022 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 26 September and 2 October 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Federico Coria | 71 | 1 |
 GER | Daniel Altmaier | 97 | 2 |
 PER | |||
| ARG | Camilo Ugo Carabelli | 119 | 4 |
| ARG | Facundo Bagnis | 120 | 5 |
 BRA | Felipe Meligeni Alves | 144 | 6 |
| ARG | Santiago Rodríguez Taverna | 159 | 7 |
| GER | Yannick Hanfmann | 170 | 8 |
The following players received wildcards into the singles main draw:
Román Andrés Burruchaga Lautaro Midón Juan Bautista OteguiThe following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Nicolás Álvarez Hernán Casanova Facundo Juárez Wilson Leite Ignacio Monzón Thiago Seyboth Wild The following player received entry as a lucky loser:
Juan Manuel Cerúndolo def. Camilo Ugo Carabelli 6–4, 2–6, 7–5. Guido Andreozzi / Guillermo Durán def. Román Andrés Burruchaga / Facundo Díaz Acosta 6–0, 7–5.
