| 2022 Upper Austria Open | |
|---|---|
| Date | 2–8 May |
| Edition | 1st |
| Surface | Clay |
| Location | Mauthausen, Austria |
| Champions | |
| Singles | |
 Jurij Rodionov | |
| Doubles | |
 Sander Arends / David Pel | |
The 2022 Danube Upper Austria Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mauthausen, Austria between 2 and 8 May 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 AUS | John Millman | 79 | 1 |
 CZE | Jiří Lehečka | 88 | 2 |
 COL | Daniel Elahi Galán | 105 | 3 |
 SVK | |||
 MDA | Radu Albot | 121 | 5 |
 GER | Mats Moraing | 126 | 6 |
| CZE | Zdeněk Kolář | 137 | 7 |
| AUT | Dennis Novak | 149 | 8 |
| Egor Gerasimov | 150 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Nerman Fatić Lucas Miedler 
Matej Sabanov 
Nikolás Sánchez Izquierdo 
Alexander Shevchenko 
Máté Valkusz The following player received entry as a lucky loser:
Jurij Rodionov def. Jiří Lehečka 6–4, 6–4. Sander Arends / David Pel def. Johannes Härteis / 
Benjamin Hassan 6–4, 6–3.