| 2022 Istanbul Challenger | |
|---|---|
| Date | 12–18 September |
| Edition | 36th |
| Surface | Hard |
| Location | Istanbul, Turkey |
| Champions | |
| Singles | |
 Radu Albot | |
| Doubles | |
 Purav Raja / Divij Sharan | |
The 2022 Istanbul Challenger was a professional tennis tournament played on hardcourts. It was the 36th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Istanbul, Turkey between 12 and 18 September 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 AUS | James Duckworth | 83 | 1 |
| MDA | Radu Albot | 106 | 2 |
 ESP | Fernando Verdasco | 122 | 3 |
 FRA | Geoffrey Blancaneaux | 148 | 4 |
 GBR | Paul Jubb | 206 | 5 |
| FRA | Laurent Lokoli | 217 | 6 |
 AUT | Sebastian Ofner | 218 | 7 |
| ESP | Nicolás Álvarez Varona | 220 | 8 |
The following players received wildcards into the singles main draw:
Berk İlkel Koray Kırcı 
Aleksandre Metreveli The following players received entry from the qualifying draw:
Sarp Ağabigün Cengiz Aksu Térence Atmane 
Marek Gengel Dominik Palán
Beibit Zhukayev The following player received entry as a lucky loser:
Bogdan Ionuț Apostol Radu Albot def. Lukáš Rosol 6–2, 6–0. Purav Raja / Divij Sharan def. Arjun Kadhe / 
Fernando Romboli 6–4, 3–6, [10–8].