| 2022 Mexico City Open | |
|---|---|
| Date | 4–10 April |
| Edition | 1st |
| Surface | Clay |
| Location | Mexico City, Mexico |
| Champions | |
| Singles | |
 Marc-Andrea Hüsler | |
| Doubles | |
 Nicolás Jarry /  Matheus Pucinelli de Almeida | |
The 2022 Mexico City Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mexico City, Mexico between 4 and 10 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ARG | Facundo Bagnis | 104 | 1 |
| ARG | Tomás Martín Etcheverry | 108 | 2 |
 USA | Stefan Kozlov | 120 | 3 |
 SVK | Andrej Martin | 128 | 4 |
| ARG | Juan Ignacio Londero | 130 | 5 |
| USA | Ernesto Escobedo | 133 | 6 |
| CHI | Nicolás Jarry | 142 | 7 |
 GBR | Jay Clarke | 168 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mateus Alves 
Nicolás Barrientos Nick Chappell 
Elmar Ejupovic Gilbert Klier Júnior Keegan Smith Marc-Andrea Hüsler def. Tomás Martín Etcheverry 6–4, 6–2. Nicolás Jarry / Matheus Pucinelli de Almeida def. 
Jonathan Eysseric / 
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