| 2022 Matsuyama Challenger | |
|---|---|
| Date | 7–13 November |
| Edition | 1st |
| Category | ATP Challenger 80 |
| Surface | Hard |
| Location | Matsuyama, Japan |
| Champions | |
| Singles | |
 Hong Seong-chan | |
| Doubles | |
 Andrew Harris / John-Patrick Smith | |
The 2022 Matsuyama Challenger was a professional tennis tournament played on hard courts. It was the 1st edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Matsuyama, Japan between 7 and 13 November 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| AUS | |||
| AUS | Rinky Hijikata | 159 | 2 |
| AUS | |||
 JPN | Kaichi Uchida | 172 | 4 |
 FRA | Benoît Paire | 173 | 5 |
 BIH | Damir Džumhur | 179 | 6 |
| AUS | Li Tu | 197 | 7 |
| JPN | Rio Noguchi | 202 | 8 |
The following players received wildcards into the singles main draw:
Sho Katayama Yusuke Kusuhara Shintaro Mochizuki The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Hong Seong-chan 
Jason Jung 
Ergi Kırkın Koki Matsuda
Mukund Sasikumar Shuichi SekiguchiThe following players received entry as lucky losers:
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