| 2022 Cali Open | |
|---|---|
| Date | 27 June – 2 July |
| Edition | 1st |
| Surface | Clay |
| Location | Cali, Colombia |
| Champions | |
| Singles | |
 Facundo Mena | |
| Doubles | |
 Malek Jaziri /  Adrián Menéndez Maceiras | |
The 2022 Cali Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cali, Colombia between 27 June and 2 July 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CHI | Tomás Barrios Vera | 131 | 1 |
| ARG | Facundo Mena | 162 | 2 |
| ARG | Juan Pablo Ficovich | 168 | 3 |
 BRA | Felipe Meligeni Alves | 213 | 4 |
| ARG | Francisco Comesaña | 239 | 5 |
 AUT | Gerald Melzer | 245 | 6 |
| CHI | Gonzalo Lama | 250 | 7 |
 SRB | Miljan Zekić | 271 | 8 |
The following players received wildcards into the singles main draw:
Tomás Barrios Vera 
Mateo Gómez Andrés Urrea The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mateus Alves Román Andrés Burruchaga 
Nick Chappell 
Chung Yun-seong Juan Bautista Otegui Matías Zukas Facundo Mena def. Miljan Zekić 6–2, 7–6(7–3). Malek Jaziri / Adrián Menéndez Maceiras def. Keegan Smith / Evan Zhu 7–5, 6–4.The 2017 Tiburon Challenger was a professional tennis tournament played on outdoor hard courts. It was the eleventh edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Tiburon, United States between 25 September and 1 October 2017.
The 2019 RBC Tennis Championships of Dallas was a professional tennis tournament played on hard courts. It was the 22nd edition of the tournament and part of the 2019 ATP Challenger Tour. It took place in Dallas, United States between 4 and 10 February 2019.
The 2019 Challenger Banque Nationale de Drummondville was a professional tennis tournament played on indoor hard courts. It was the 13th edition of the tournament and part of the 2019 ATP Challenger Tour. It took place in Drummondville, Canada between March 11 and March 17, 2019.
The 2019 Play In Challenger was a professional tennis tournament played on indoor hard courts. It was the second edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Lille, France, between 18 and 24 March 2019.
The 2019 Open Harmonie mutuelle was a professional tennis tournament played on hard courts. It was the sixteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Saint-Brieuc, France between 25 and 31 March 2019.
The 2019 Savannah Challenger was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Savannah, Georgia, United States between 29 April and 5 May 2019.
The 2019 Challenger Banque Nationale de Gatineau was a professional tennis tournament played on outdoor hard courts. It was the 4th edition of the tournament for men and the 6th for women, and it was part of the 2019 ATP Challenger Tour and the 2019 ITF Women's World Tennis Tour. It took place in Gatineau, Canada between July 15 and 21, 2019.
The 2019 Challenger Banque Nationale de Granby was a professional tennis tournament played on outdoor hard courts. It was the twenty-sixth (men) and ninth (women) editions of the tournament which was part of the 2019 ATP Challenger Tour and the 2019 ITF Women's World Tennis Tour. It took place in Granby, Quebec, Canada between 22 and 28 July 2019.
The 2019 Chengdu Challenger was a professional tennis tournament played on hard courts. It was the 4th edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Chengdu, China between 29 July and 4 August 2019.
The 2019 Tiburon Challenger was a professional tennis tournament played on outdoor hard courts. It was the thirteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Tiburon, United States between 23 and 29 September 2019.
The 2020 RBC Tennis Championships of Dallas was a professional tennis tournament played on hard courts. It was the 23rd edition of the tournament and part of the 2020 ATP Challenger Tour. It took place in Dallas, United States between 3 and 9 February 2020.
The 2022 Città di Forlì III was a professional tennis tournament played on indoor hard courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Forlì, Italy between 17 and 23 January 2022.
The 2022 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Monterrey, Mexico from 7 to 13 March 2022.
The 2022 Ostra Group Open was a professional tennis tournament played on clay courts. It was the 19th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Ostrava, Czech Republic between 25 April and 1 May.
The 2022 Shymkent Challenger was a professional tennis tournament played on clay courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Shymkent, Kazakhstan between 9 and 14 May 2022.
The 2022 Shymkent Challenger II was a professional tennis tournament played on clay courts. It was the sixth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Shymkent, Kazakhstan between 16 and 21 May 2022.
The 2022 Indy Challenger was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Indianapolis, United States between 18 and 24 July 2022.
The 2022 Winnipeg National Bank Challenger was a professional tennis tournament played on outdoor hard courts. It was the 5th edition of the tournament and part of the 2022 ATP Challenger Tour. It took place in Winnipeg, Manitoba, Canada between July 25 and July 31, 2022.
The 2022 Lexington Challenger is a professional tennis tournament played on outdoor hard courts. It is the twenty-seventh edition of the tournament which is part of the 2022 ATP Challenger Tour, and the twenty-fifth edition of the tournament which is part of the 2022 ITF Women's World Tennis Tour. It takes place in Lexington, Kentucky, United States between 1 and 7 August 2022.
The 2022 Chicago Men's Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Chicago, United States between 8 and 14 August 2022.
