| 2022 Cali Open | |
|---|---|
| Date | 27 June – 2 July |
| Edition | 1st |
| Surface | Clay |
| Location | Cali, Colombia |
| Champions | |
| Singles | |
 Facundo Mena | |
| Doubles | |
 Malek Jaziri /  Adrián Menéndez Maceiras | |
The 2022 Cali Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cali, Colombia between 27 June and 2 July 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CHI | Tomás Barrios Vera | 131 | 1 |
| ARG | Facundo Mena | 162 | 2 |
| ARG | Juan Pablo Ficovich | 168 | 3 |
 BRA | Felipe Meligeni Alves | 213 | 4 |
| ARG | Francisco Comesaña | 239 | 5 |
 AUT | Gerald Melzer | 245 | 6 |
| CHI | Gonzalo Lama | 250 | 7 |
 SRB | Miljan Zekić | 271 | 8 |
The following players received wildcards into the singles main draw:
Tomás Barrios Vera 
Mateo Gómez Andrés Urrea The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mateus Alves Román Andrés Burruchaga 
Nick Chappell 
Chung Yun-seong Juan Bautista Otegui Matías Zukas Facundo Mena def. Miljan Zekić 6–2, 7–6(7–3). Malek Jaziri / Adrián Menéndez Maceiras def. Keegan Smith / Evan Zhu 7–5, 6–4.