| 2022 Split Open | |
|---|---|
| Date | 18–24 April 2022 |
| Edition | 4th |
| Surface | Clay |
| Location | Split, Croatia |
| Champions | |
| Singles | |
 Christopher O'Connell | |
| Doubles | |
 Nathaniel Lammons /  Albano Olivetti | |
The 2022 Split Open was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Split, Croatia between 18 and 24 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CZE | Zdeněk Kolář | 141 | 1 |
 SRB | Nikola Milojević | 148 | 2 |
| AUS | Christopher O'Connell | 150 | 3 |
 TUR | Altuğ Çelikbilek | 174 | 4 |
 ITA | Thomas Fabbiano | 178 | 5 |
| FRA | Enzo Couacaud | 179 | 6 |
 ARG | Marco Trungelliti | 194 | 7 |
 POL | Kacper Żuk | 200 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
Christopher O'Connell def. 
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