| 2022 AON Open Challenger | |
|---|---|
| Date | 19–25 September |
| Edition | 18th |
| Surface | Clay |
| Location | Genoa, Italy |
| Champions | |
| Singles | |
 Thiago Monteiro | |
| Doubles | |
 Dustin Brown /  Andrea Vavassori | |
The 2022 AON Open Challenger was a professional tennis tournament played on clay courts. It was the eighteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Genoa, Italy between 19 and 25 September 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Albert Ramos Viñolas | 40 | 1 |
| BRA | Thiago Monteiro | 65 | 2 |
 FRA | Corentin Moutet | 84 | 3 |
 SRB | Dušan Lajović | 92 | 4 |
| ESP | Pablo Andújar | 113 | 5 |
 ARG | Federico Delbonis | 118 | 6 |
| ITA | Francesco Passaro | 125 | 7 |
| ITA | Marco Cecchinato | 146 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Andrey Chepelev Matteo Gigante 
Sandro Kopp
Martin Krumich Matteo Martineau Gabriele PirainoThe following player received entry as a lucky loser:
Oscar José Gutierrez Thiago Monteiro def. Andrea Pellegrino 6–1, 7–6(7–2). Dustin Brown / Andrea Vavassori def. Roman Jebavý / Adam Pavlásek 6–2, 6–2.The 2016 Adriatic Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Fano, Italy from 8 to 14 August 2016.
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