| 2022 Open Sopra Steria de Lyon | |
|---|---|
| Date | 6–12 June |
| Edition | 6th |
| Surface | Clay |
| Location | Lyon, France |
| Champions | |
| Singles | |
 Corentin Moutet | |
| Doubles | |
 Romain Arneodo / Jonathan Eysseric | |
The 2022 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 6th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Lyon, France, between 6 and 12 June 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ARG | Federico Coria | 54 | 1 |
| FRA | Richard Gasquet | 70 | 2 |
 BOL | Hugo Dellien | 90 | 3 |
 ESP | Pablo Andújar | 98 | 4 |
 POR | Nuno Borges | 134 | 5 |
 CHI | |||
| FRA | Corentin Moutet | 138 | 7 |
| FRA | Manuel Guinard | 145 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Corentin Moutet def. Pedro Cachin 6–4, 6–4. Romain Arneodo / Jonathan Eysseric def. 
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