| 2021 Open Sopra Steria de Lyon | |
|---|---|
| Date | 7–13 June |
| Edition | 5th |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | Lyon, France |
| Champions | |
| Singles | |
 Pablo Cuevas | |
| Doubles | |
| Martín Cuevas / Pablo Cuevas | |
The 2021 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 5th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lyon, France, between 7 and 13 June 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| URU | Pablo Cuevas | 92 | 1 |
 ESP | Fernando Verdasco | 99 | 2 |
 ARG | Facundo Bagnis | 104 | 3 |
 COL | Daniel Elahi Galán | 107 | 4 |
 JPN | Taro Daniel | 113 | 5 |
 FRA | Benjamin Bonzi | 116 | 6 |
| ARG | Francisco Cerúndolo | 117 | 7 |
 GER | Cedrik-Marcel Stebe | 135 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Pablo Cuevas def. 
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