| 2021 Open International de Tennis de Roanne | |
|---|---|
| Date | 8–14 November |
| Edition | 1st |
| Surface | Hard (Indoor) |
| Location | Roanne, France |
| Champions | |
| Singles | |
 Hugo Grenier | |
| Doubles | |
 Lloyd Glasspool /  Harri Heliövaara | |
The 2021 Open International de Tennis de Roanne was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Roanne, France between 8 and 14 November 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Benoît Paire | 47 | 1 |
| FRA | Richard Gasquet | 74 | 2 |
 CZE | Jiří Veselý | 86 | 3 |
 SWE | Mikael Ymer | 97 | 4 |
 SUI | Henri Laaksonen | 98 | 5 |
 AUT | |||
 MDA | Radu Albot | 127 | 7 |
| FRA | Antoine Hoang | 168 | 8 |
| FRA | Hugo Grenier | 183 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Gabriel Debru Calvin Hemery 
Georgii Kravchenko
Alexey Vatutin The following players received entry as lucky losers:
Hugo Grenier def. 
Hiroki Moriya 6–2, 6–3. Lloyd Glasspool / Harri Heliövaara def. 
Romain Arneodo / Albano Olivetti 7–6(7–5), 6–7(5–7), [12–10].The 2021 Open de Oeiras II was a professional tennis tournament played on clay courts. It was the second edition of the tournament, part of the 2021 ATP Challenger Tour. It took place in Oeiras, Portugal between 5 and 11 April 2021.
The 2021 Open de Oeiras IV was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Oeiras, Portugal between 24 and 30 May 2021.
The 2021 Internazionali di Tennis Città di Todi was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Todi, Italy between 12 and 18 July 2021.
The 2021 Open de Tenis Ciudad de Pozoblanco was a professional tennis tournament played on hard courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Pozoblanco, Spain between 19 and 25 July 2021.
The 2021 Internazionali di Tennis Città di Verona was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Verona, Italy, between 16 and 22 August 2021.
The 2021 Kyiv Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Kyiv, Ukraine between 6 and 12 September 2021.
The 2021 Open de Rennes was a professional tennis tournament played on hard courts. It was the fifteenth edition of the tournament and part of the 2021 ATP Challenger Tour. It took place in Rennes, France between 13 and 19 September 2021.
The 2021 Braga Open was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Braga, Portugal between 20 and 26 September 2021.
The 2021 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts. It was the eighth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 4 and 10 October 2021.
The 2021 Challenger de Santiago II was a professional tennis tournament played on clay courts. It was the 14th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 4 and 10 October 2021.
The 2021 Charlottesville Men's Pro Challenger was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour, taking place in Charlottesville, United States from November 1 to 7, 2021.
The 2021 Trofeo Faip–Perrel was a professional tennis tournament played on hard courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Bergamo, Italy between 1 and 7 November 2021.
The 2021 Challenger Ciudad de Guayaquil is a professional tennis tournament played on clay courts. It is the seventeenth edition of the tournament which is part of the 2021 ATP Challenger Tour. It will take place in Guayaquil, Ecuador between 1 and 7 November 2021.
The 2021 Tenerife Challenger is a professional tennis tournament played on hard courts. It is the first edition of the tournament which is part of the 2021 ATP Challenger Tour. It will take place in Tenerife, Spain between 1 and 7 November 2021.
The 2021 Teréga Open Pau–Pyrénées was a professional tennis tournament played on indoor hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Pau, France between 15 and 21 November 2021.
The 2021 Tali Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Helsinki, Finland between November 15 and November 21, 2021.
The 2021 Bahrain Ministry of Interior Tennis Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Manama, Bahrain between 22 and 28 November 2021.
The 2021 São Paulo Challenger de Tênis was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in São Paulo, Brazil between 29 November and 5 December 2021.
The 2021 Città di Forlì II was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Forlì, Italy between 29 November and 5 December 2021.
The 2021 Rio Tennis Classic was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Rio de Janeiro, Brazil from 13 to 19 December 2021.
