| 2021 Open International de Tennis de Roanne | |
|---|---|
| Date | 8–14 November |
| Edition | 1st |
| Surface | Hard (Indoor) |
| Location | Roanne, France |
| Champions | |
| Singles | |
 Hugo Grenier | |
| Doubles | |
 Lloyd Glasspool /  Harri Heliövaara | |
The 2021 Open International de Tennis de Roanne was a professional tennis tournament played on indoor hardcourts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Roanne, France between 8 and 14 November 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Benoît Paire | 47 | 1 |
| FRA | Richard Gasquet | 74 | 2 |
 CZE | Jiří Veselý | 86 | 3 |
 SWE | Mikael Ymer | 97 | 4 |
 SUI | Henri Laaksonen | 98 | 5 |
 AUT | |||
 MDA | Radu Albot | 127 | 7 |
| FRA | Antoine Hoang | 168 | 8 |
| FRA | Hugo Grenier | 183 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Gabriel Debru Calvin Hemery 
Georgii Kravchenko
Alexey Vatutin The following players received entry as lucky losers:
Hugo Grenier def. 
Hiroki Moriya 6–2, 6–3. Lloyd Glasspool / Harri Heliövaara def. 
Romain Arneodo / Albano Olivetti 7–6(7–5), 6–7(5–7), [12–10].
