| 2021 Sparkassen ATP Challenger | |
|---|---|
| Date | 8–14 November |
| Edition | 12th |
| Surface | Hard (Indoor) |
| Location | Ortisei, Italy |
| Champions | |
| Singles | |
 Oscar Otte | |
| Doubles | |
 Antonio Šančić /  Tristan-Samuel Weissborn | |
The 2021 Sparkassen ATP Challenger was a professional tennis tournament played on indoor hard courts in Ortisei, Italy between 8 and 14 November 2021. It was the twelfth edition of the tournament and was part of the 2021 ATP Challenger Tour.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| GER | Oscar Otte | 126 | 1 |
 USA | Maxime Cressy | 133 | 2 |
 FRA | Quentin Halys | 146 | 3 |
 ECU | Emilio Gómez | 149 | 4 |
 ITA | Federico Gaio | 151 | 5 |
 ESP | Fernando Verdasco | 165 | 6 |
 SUI | Marc-Andrea Hüsler | 186 | 7 |
| ITA | Alessandro Giannessi | 192 | 8 |
The following players received wildcards into the singles main draw:
Matteo Arnaldi Luca Nardi Alexander WeisThe following players received entry from the qualifying draw:
Alexander Cozbinov 
Nerman Fatić Lucas Miedler Tobias Simon Oscar Otte def. Maxime Cressy 7–6(7–5), 6–4. Antonio Šančić / Tristan-Samuel Weissborn def. Alexander Erler / Lucas Miedler 7–6(10–8), 4–6, [10–8].The 2016 Adriatic Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Fano, Italy from 8 to 14 August 2016.
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