| 2021 Challenger de Buenos Aires | |
|---|---|
| Date | 18–24 October |
| Edition | 10th |
| Surface | Clay |
| Location | Buenos Aires, Argentina |
| Champions | |
| Singles | |
 Sebastián Báez | |
| Doubles | |
 Luciano Darderi / Juan Bautista Torres | |
The 2021 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the tenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 18 and 24 October 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 BRA | Thiago Monteiro | 92 | 1 |
| ARG | Juan Manuel Cerúndolo | 103 | 2 |
| ARG | Francisco Cerúndolo | 110 | 3 |
 PER | Juan Pablo Varillas | 127 | 4 |
 BOL | Hugo Dellien | 128 | 5 |
| BRA | Thiago Seyboth Wild | 129 | 6 |
| ARG | Sebastián Báez | 140 | 7 |
| ARG | Tomás Martín Etcheverry | 144 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Francisco Comesaña 
Martín Cuevas 
Carlos Gómez-Herrera Ignacio Monzón Sebastián Báez def. Thiago Monteiro 6–4, 6–0. Luciano Darderi / Juan Bautista Torres def. Hernán Casanova / Santiago Rodríguez Taverna 7–6(7–5), 7–6(12–10).The 2010 Copa Petrobras Buenos Aires was a professional tennis tournament played on red clay courts. It was the seventh edition of the tournament which was part of the 2010 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 4 and 11 October 2010.
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