| 2021 Murcia Open | |
|---|---|
| Date | 27 September – 3 October |
| Edition | 2nd |
| Surface | Clay |
| Location | Murcia, Spain |
| Champions | |
| Singles | |
 Tallon Griekspoor | |
| Doubles | |
 Raúl Brancaccio / Flavio Cobolli | |
The 2021 Murcia Open was a professional tennis tournament played on clay courts. It was the 2nd edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Murcia, Spain, between 27 September and 3 October 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Roberto Carballés Baena | 89 | 1 |
| NED | Tallon Griekspoor | 132 | 2 |
 AUS | Marc Polmans | 165 | 3 |
| ESP | Mario Vilella Martínez | 171 | 4 |
 ARG | Marco Trungelliti | 176 | 5 |
 IND | Ramkumar Ramanathan | 192 | 6 |
 SVK | Filip Horanský | 204 | 7 |
 FRA | Mathias Bourgue | 213 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
Joris De Loore Jeroen VannesteThe following players received entry from the qualifying draw:
Tallon Griekspoor def. Roberto Carballés Baena 3–6, 7–5, 6–3. Raúl Brancaccio / Flavio Cobolli def. Alberto Barroso Campos / Roberto Carballés Baena 6–3, 7–6(7–4).
