| 2021 Pekao Szczecin Open | |
|---|---|
| Date | 13–19 September |
| Edition | 28th |
| Surface | Clay |
| Location | Szczecin, Poland |
| Champions | |
| Singles | |
 Zdeněk Kolář | |
| Doubles | |
 Santiago González /  Andrés Molteni | |
The 2021 Pekao Szczecin Open was a professional tennis tournament played on clay courts. It was the 28th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Szczecin, Poland between 13 and 19 September 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Albert Ramos Viñolas | 48 | 1 |
| ESP | Pablo Andújar | 74 | 2 |
| ESP | |||
 ITA | Marco Cecchinato | 81 | 4 |
| CZE | Jiří Veselý | 90 | 5 |
 BRA | Thiago Monteiro | 93 | 6 |
| ESP | Roberto Carballés Baena | 95 | 7 |
| ITA | Stefano Travaglia | 100 | 8 |
1 Rankings are as of 30 August 2021. [1]
The following players received wildcards into the singles main draw:
Paweł Ciaś Daniel Michalski Albert Ramos Viñolas The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Zdeněk Kolář def. Kamil Majchrzak 7–6(7–4), 7–5. Santiago González / Andrés Molteni def. 
André Göransson / 
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