| 2021 Saint Petersburg Challenger II | |
|---|---|
| Date | 8–14 March |
| Edition | 2nd |
| Surface | Hard (Indoor) |
| Location | Saint Petersburg, Russia |
| Champions | |
| Singles | |
 Evgenii Tiurnev | |
| Doubles | |
 Jesper de Jong / Sem Verbeek | |
The 2021 Saint Petersburg Challenger II was a professional tennis tournament played on hard courts. It was the second edition of the Saint Petersburg Challenger which was part of the 2021 ATP Challenger Tour. It took place in Saint Petersburg, Russia between 8 and 14 March 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| RUS | Roman Safiullin | 164 | 1 |
 KAZ | Dmitry Popko | 183 | 2 |
 TUR | Cem İlkel | 210 | 3 |
 ROU | Marius Copil | 224 | 4 |
 GER | Rudolf Molleker | 226 | 5 |
 POL | Kacper Żuk | 232 | 6 |
 USA | Christopher Eubanks | 239 | 7 |
| RUS | Teymuraz Gabashvili | 249 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Evgenii Tiurnev def. Kacper Żuk 6–4, 6–2. Jesper de Jong / Sem Verbeek def. Konstantin Kravchuk / Denis Yevseyev 6–1, 3–6, [10–5].
