| 2021 Garden Open | |
|---|---|
| Date | 19–25 April |
| Edition | 12th |
| Surface | Clay |
| Location | Rome, Italy |
| Champions | |
| Singles | |
 Andrea Pellegrino | |
| Doubles | |
 Sadio Doumbia / Fabien Reboul | |
The 2021 Garden Open was a professional tennis tournament played on clay courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Rome, Italy between 19 and 25 April 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Grégoire Barrère | 116 | 1 |
 BOL | Hugo Dellien | 122 | 2 |
| ITA | Paolo Lorenzi | 154 | 3 |
 AUT | Sebastian Ofner | 159 | 4 |
| FRA | Hugo Gaston | 160 | 5 |
 PER | Juan Pablo Varillas | 161 | 6 |
| ITA | Lorenzo Giustino | 168 | 7 |
 CAN | Steven Diez | 176 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Andrea Pellegrino def. Hugo Gaston 3–6, 6–2, 6–1. Sadio Doumbia / Fabien Reboul def. Paolo Lorenzi / Juan Pablo Varillas 7–6(7–5), 7–5.The 2016 Adriatic Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Fano, Italy from 8 to 14 August 2016.
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