| 2021 Tenerife Challenger | |
|---|---|
| Date | 1–7 November |
| Edition | 1st |
| Surface | Hard |
| Location | Tenerife, Spain |
| Champions | |
| Singles | |
 Tallon Griekspoor | |
| Doubles | |
 Nuno Borges / Francisco Cabral | |
The 2021 Tenerife Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Tenerife, Spain between 1 and 7 November 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| NED | Tallon Griekspoor | 89 | 1 |
 ESP | Feliciano López | 109 | 2 |
| ESP | Fernando Verdasco | 144 | 3 |
 FRA | Quentin Halys | 148 | 4 |
 ECU | Emilio Gómez | 149 | 5 |
 TUR | Altuğ Çelikbilek | 164 | 6 |
 SWE | Elias Ymer | 168 | 7 |
| POR | João Sousa | 173 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Yan Bondarevskiy
David Ionel 
Vladyslav Orlov Alexander Shevchenko The following player received entry as a lucky loser:
Tallon Griekspoor def. Feliciano López 6–4, 6–4. Nuno Borges / Francisco Cabral def. 
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