| 2021 Challenger Ciudad de Guayaquil | |
|---|---|
| Date | 1–7 November |
| Edition | 17th |
| Surface | Clay |
| Location | Guayaquil, Ecuador |
| Champions | |
| Singles | |
 Alejandro Tabilo | |
| Doubles | |
 Jesper de Jong / Bart Stevens | |
The 2021 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the seventeenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 1 and 7 November 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Jaume Munar | 75 | 1 |
 ARG | Facundo Bagnis | 81 | 2 |
 COL | Daniel Elahi Galán | 106 | 3 |
| ARG | Sebastián Báez | 112 | 4 |
| ARG | Francisco Cerúndolo | 113 | 5 |
 BRA | Thiago Seyboth Wild | 126 | 6 |
 BOL | Hugo Dellien | 128 | 7 |
| ARG | Tomás Martín Etcheverry | 133 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Nicolás Álvarez Daniel Dutra da Silva Alejandro González Facundo JuárezThe following player received entry as a lucky loser:
Alejandro Tabilo def. Jesper de Jong 6–1, 7–5. Jesper de Jong / Bart Stevens def. 
Diego Hidalgo / Cristian Rodríguez 7–5, 6–2.The 2011 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which is part of the 2011 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 21 and 27 November 2011.
The 2012 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament, which was part of the 2012 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 5 and 10 November 2012.
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