| 2021 Biella Challenger V | |
|---|---|
| Date | 3–9 May 2021 |
| Edition | 14th |
| Surface | Clay |
| Location | Biella, Italy |
| Champions | |
| Singles | |
 Juan Pablo Varillas | |
| Doubles | |
 André Göransson /  Nathaniel Lammons | |
The 2021 Biella Challenger V was a professional tennis tournament played on outdoor red clay courts. It was part of the 2021 ATP Challenger Tour. It took place in Biella, Italy between 3 and 9 May 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 POR | Pedro Sousa | 113 | 1 |
 BOL | Hugo Dellien | 125 | 2 |
| USA | Mackenzie McDonald | 127 | 3 |
 GER | Cedrik-Marcel Stebe | 134 | 4 |
 ITA | Federico Gaio | 138 | 5 |
 FRA | Hugo Gaston | 147 | 6 |
| PER | Juan Pablo Varillas | 150 | 7 |
 JPN | Go Soeda | 154 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Juan Pablo Varillas def. 
Guido Andreozzi 6–3, 6–1. André Göransson / Nathaniel Lammons def. 
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