| 2021 Puerto Vallarta Open | |
|---|---|
| Date | 22–28 November |
| Edition | 3rd |
| Surface | Hard |
| Location | Puerto Vallarta, Mexico |
| Champions | |
| Singles | |
 Daniel Altmaier | |
| Doubles | |
 Gijs Brouwer /  Reese Stalder | |
The 2021 Puerto Vallarta Open was a professional tennis tournament played on hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Puerto Vallarta, Mexico between 22 and 28 November 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 URU | Pablo Cuevas | 95 | 1 |
| GER | Daniel Altmaier | 98 | 2 |
 CHI | Alejandro Tabilo | 141 | 3 |
| USA | Ernesto Escobedo | 163 | 4 |
| USA | Michael Mmoh | 247 | 5 |
| USA | Christian Harrison | 252 | 6 |
 TPE | Wu Tung-lin | 264 | 7 |
 JPN | Tatsuma Ito | 283 | 8 |
The following players received wildcards into the singles main draw:
Milledge Cossu
Gerardo López Villaseñor 
Shang Juncheng The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Liam Draxl Alex Hernández Christian Langmo Govind Nanda Daniel Altmaier def. Alejandro Tabilo 6–3, 3–6, 6–3. Gijs Brouwer / Reese Stalder def. Hans Hach Verdugo / Miguel Ángel Reyes-Varela 6–4, 6–4.The 2018 Puerto Vallarta Open was a professional tennis tournament played on hard courts. It was the 1st edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Puerto Vallarta, Mexico between 30 April and 5 May.
The 2019 Puerto Vallarta Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Puerto Vallarta, Mexico between 29 April and 5 May 2019.
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