| 2021 Lima Challenger II | |
|---|---|
| Date | 25–31 October |
| Edition | 16th |
| Surface | Clay |
| Location | Lima, Peru |
| Champions | |
| Singles | |
 Nicolás Jarry | |
| Doubles | |
 Sergio Galdós /  Gonçalo Oliveira | |
The 2021 Lima Challenger II was a professional tennis tournament played on clay courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lima, Peru between 25 and 31 October 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 BRA | |||
 ARG | Juan Manuel Cerúndolo | 102 | 2 |
 COL | Daniel Elahi Galán | 107 | 3 |
| ARG | |||
| ARG | |||
| BRA | Thiago Seyboth Wild | 126 | 6 |
 BOL | Hugo Dellien | 128 | 7 |
| PER | Juan Pablo Varillas | 129 | 8 |
| ARG | Tomás Martín Etcheverry | 138 | 9 |
| CHI | Marcelo Tomás Barrios Vera | 145 | 10 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Alexis Galarneau Cristian Rodríguez 
Jean Thirouin Nicolás Jarry def. Juan Manuel Cerúndolo 6–2, 7–5. Sergio Galdós / Gonçalo Oliveira def. Marcelo Tomás Barrios Vera / Alejandro Tabilo 6–2, 2–6, [10–5].The 2017 Lima Challenger was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Lima, Peru between October 23 and October 29, 2017.
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