| 2021 Biella Challenger VII | |
|---|---|
| Date | 31 May – 6 June 2021 |
| Edition | 16th |
| Surface | Clay |
| Location | Biella, Italy |
| Champions | |
| Singles | |
 Holger Rune | |
| Doubles | |
 Tomás Martín Etcheverry / Renzo Olivo | |
The 2021 Biella Challenger VII was a professional tennis tournament played on outdoor red clay courts. It was part of the 2021 ATP Challenger Tour. It took in Biella, Italy between 31 May and 6 June 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 PER | Juan Pablo Varillas | 130 | 1 |
 SRB | Nikola Milojević | 140 | 2 |
 GER | Daniel Altmaier | 145 | 3 |
| SRB | Danilo Petrović | 165 | 4 |
 POR | Frederico Ferreira Silva | 168 | 5 |
 POL | Kacper Żuk | 173 | 6 |
 SVK | Martin Kližan | 176 | 7 |
 ITA | Lorenzo Giustino | 178 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
Holger Rune def. Marco Trungelliti 6–3, 5–7, 7–6(7–5). Tomás Martín Etcheverry / Renzo Olivo def. 
Luis David Martínez / 
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