| 2021 Lima Challenger | |
|---|---|
| Date | 27 September – 3 October |
| Edition | 15th |
| Surface | Clay |
| Location | Lima, Peru |
| Champions | |
| Singles | |
 Hugo Dellien | |
| Doubles | |
 Julian Lenz /  Gerald Melzer | |
The 2021 Lima Challenger was a professional tennis tournament played on clay courts. It was the fifteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lima, Peru between 27 September and 3 October 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ARG | Francisco Cerúndolo | 103 | 1 |
| ARG | Juan Manuel Cerúndolo | 106 | 2 |
| GER | Daniel Altmaier | 112 | 3 |
 PER | Juan Pablo Varillas | 121 | 4 |
| BOL | Hugo Dellien | 141 | 5 |
| ARG | Renzo Olivo | 202 | 6 |
| ARG | Juan Pablo Ficovich | 236 | 7 |
| ARG | Camilo Ugo Carabelli | 244 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Hugo Dellien def. Camilo Ugo Carabelli 6–3, 7–5. Julian Lenz / Gerald Melzer def. 
Nicolás Barrientos / 
Fernando Romboli 7–6(7–4), 7–6(7–3).
