| 2021 Salinas Challenger | |
|---|---|
| Date | 19–25 April |
| Edition | 20th |
| Surface | Hard |
| Location | Salinas, Ecuador |
| Champions | |
| Singles | |
 Nicolás Jarry | |
| Doubles | |
 Miguel Ángel Reyes-Varela /  Fernando Romboli | |
The 2021 Salinas Challenger was a professional tennis tournament played on hard courts. It was the 20th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Salinas, Ecuador between 19 and 25 April 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 JPN | Yasutaka Uchiyama | 108 | 1 |
| CHI | Alejandro Tabilo | 163 | 2 |
 ECU | Emilio Gómez | 183 | 3 |
 USA | Christopher Eubanks | 233 | 4 |
| CHI | Marcelo Tomás Barrios Vera | 239 | 5 |
 TUR | Altuğ Çelikbilek | 251 | 6 |
| JPN | Hiroki Moriya | 266 | 7 |
| ECU | Roberto Quiroz | 273 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Nicolás Jarry def. 
Nicolás Mejía 7–6(9–7), 6–1. Miguel Ángel Reyes-Varela / Fernando Romboli def. Diego Hidalgo / 
Skander Mansouri 7–5, 4–6, [10–2].The 2013 Challenger ATP de Salinas Diario Expreso was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2013 ATP Challenger Tour. It took place in Salinas, Ecuador between February 25 and March 3, 2013.
The 2016 Milo Open Cali was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament, which is part of the 2016 ATP Challenger Tour. It took place in Cali, Colombia between 4 and 10 July 2016.
The 2016 Uruguay Open is a professional tennis tournament played on clay courts. It is the twelfth edition of the tournament which is part of the 2016 ATP Challenger Tour. It takes place in Montevideo, Uruguay between November 14 and November 20, 2016.
The 2017 Quito Challenger was a professional tennis tournament played on clay courts. It was the 21st edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Quito, Ecuador between 28 August and 3 September 2017.
The 2017 Santiago Challenger was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Santiago, Chile between 13 and 18 November 2017.
The 2019 Kentucky Bank Tennis Championships was a professional tennis tournament played on outdoor hard courts. It was the 24th (ATP) and 22nd (ITF) editions of the tournament and was part of the 2019 ATP Challenger Tour and the 2019 ITF Women's World Tennis Tour. It took place in Lexington, the United States, from 29 July–to 4 August 2019.
The 2021 Challenger Concepción was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Concepción, Chile between 15 and 21 February 2021.
The 2021 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 13th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 15 and 21 March 2021.
The 2021 Salinas Challenger II was a professional tennis tournament played on green hard courts. It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Salinas, Ecuador between 26 April and 2 May 2021.
The 2021 Orlando Open II was a professional tennis tournament played on hard courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Orlando, Florida, United States between 7 and 13 June 2021.
The 2021 Open de Tenis Ciudad de Pozoblanco was a professional tennis tournament played on hard courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Pozoblanco, Spain between 19 and 25 July 2021.
The 2021 Platzmann-Sauerland Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lüdenscheid, Germany, between 16 and 22 August 2021.
The 2021 Challenger de Santiago II was a professional tennis tournament played on clay courts. It was the 14th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 4 and 10 October 2021.
The 2021 Challenger de Santiago III was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 11 and 17 October 2021.
The 2021 Open Bogotá was a professional tennis tournament played on clay courts. It was the thirteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Bogotá, Colombia between 18 and 24 October 2021.
The 2021 Lima Challenger II was a professional tennis tournament played on clay courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Lima, Peru between 25 and 31 October 2021.
The 2021 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the seventeenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 1 and 7 November 2021.
The 2022 Santa Cruz Challenger, also known as Dove MEN + CARE Challenger Bolivia, was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 24 and 30 January 2022.
The 2022 Mexico City Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mexico City, Mexico between 4 and 10 April 2022.
The 2022 Challenger Coquimbo was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Coquimbo, Chile between 9 and 14 May 2022.
