| 2021 Split Open | |
|---|---|
| Date | 5–11 April 2021 |
| Edition | 2nd |
| Surface | Clay |
| Location | Split, Croatia |
| Champions | |
| Singles | |
 Blaž Rola | |
| Doubles | |
 Andrey Golubev / Aleksandr Nedovyesov | |
The 2021 Split Open was a professional tennis tournament played on clay courts. It was part of the 2021 ATP Challenger Tour. It took place in Split, Croatia between 5 and 11 April 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 POR | Pedro Sousa | 111 | 1 |
 AUS | Marc Polmans | 137 | 2 |
 AUT | Sebastian Ofner | 152 | 3 |
 EGY | Mohamed Safwat | 159 | 4 |
 SRB | Danilo Petrović | 160 | 5 |
| SLO | Blaž Rola | 166 | 6 |
 BEL | Kimmer Coppejans | 170 | 7 |
 SVK | Filip Horanský | 175 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Blaž Rola def. Blaž Kavčič 2–6, 6–3, 6–2. Andrey Golubev / Aleksandr Nedovyesov def. 
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