| 2021 Split Open II | |
|---|---|
| Date | 12–18 April 2021 |
| Edition | 3rd |
| Surface | Clay |
| Location | Split, Croatia |
| Champions | |
| Singles | |
 Kacper Żuk | |
| Doubles | |
| Szymon Walków / Jan Zieliński | |
The 2021 Split Open II was a professional tennis tournament played on clay courts. It was part of the 2021 ATP Challenger Tour. It took place in Split, Croatia between 12 and 18 April 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 FRA | Grégoire Barrère | 116 | 1 |
 AUS | Marc Polmans | 149 | 2 |
| FRA | Hugo Gaston | 158 | 3 |
 EGY | Mohamed Safwat | 160 | 4 |
 BEL | Kimmer Coppejans | 168 | 5 |
 ITA | Lorenzo Giustino | 169 | 6 |
 SVK | Filip Horanský | 175 | 7 |
 CAN | Steven Diez | 177 | 8 |
The following players received wildcards into the singles main draw:
Duje Ajduković Duje Kekez Nino Serdarušić The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
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