| 2021 Saint-Tropez Open | |
|---|---|
| Date | 30 August – 5 September |
| Edition | 1st |
| Surface | Hard |
| Location | Saint-Tropez, France |
| Champions | |
| Singles | |
 Benjamin Bonzi | |
| Doubles | |
 Antonio Šančić /  Artem Sitak | |
The 2021 Saint-Tropez Open was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Saint-Tropez, France between 30 August and 5 September 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Benjamin Bonzi | 94 | 1 |
 AUS | Christopher O'Connell | 126 | 2 |
| FRA | Grégoire Barrère | 136 | 3 |
 IND | Prajnesh Gunneswaran | 156 | 4 |
 RUS | Roman Safiullin | 164 | 5 |
 SWE | Elias Ymer | 169 | 6 |
 TUR | Altuğ Çelikbilek | 174 | 7 |
| AUS | Thanasi Kokkinakis | 186 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Dan Added Bogdan Bobrov Jurgen Briand
Alexis Galarneau The following players received entry as lucky losers:
Benjamin Bonzi def. Christopher O'Connell 6–7(10–12), 6–1, 0–0 ret. Antonio Šančić / Artem Sitak def. 
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