| 2021 Antalya Challenger IV | |
|---|---|
| Date | 6–12 December |
| Edition | 4th |
| Surface | Clay |
| Location | Antalya, Turkey |
| Champions | |
| Singles | |
 Evgenii Tiurnev | |
| Doubles | |
 Hsu Yu-hsiou /  Oleksii Krutykh | |
The 2021 Antalya Challenger IV was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Antalya, Turkey between 6 and 12 December 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 TUR | Cem İlkel | 144 | 1 |
 IND | |||
 CRO | Duje Ajduković | 251 | 3 |
 GBR | Ryan Peniston | 284 | 4 |
 ITA | Riccardo Bonadio | 298 | 5 |
 ESP | Javier Barranco Cosano | 305 | 6 |
 BIH | Nerman Fatić | 307 | 7 |
 SRB | |||
| RUS | Evgenii Tiurnev | 319 | 9 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Andrey Chepelev
Cezar Crețu Marsel İlhan 
Damien WengerThe following players received entry as lucky losers:
Evgenii Tiurnev def. Oleg Prihodko 3–6, 6–4, 6–4. Hsu Yu-hsiou / Oleksii Krutykh def. 
Sanjar Fayziev / 
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