| 2022 Challenger Coquimbo II | |
|---|---|
| Date | 17–23 October 2022 |
| Edition | 2nd |
| Surface | Clay |
| Location | Coquimbo, Chile |
| Champions | |
| Singles | |
 Juan Manuel Cerúndolo | |
| Doubles | |
 Franco Agamenone / Hernán Casanova | |
The 2022 Challenger Coquimbo II was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Coquimbo, Chile between 17 and 23 October 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Federico Coria | 72 | 1 |
| ARG | Tomás Martín Etcheverry | 89 | 2 |
 GER | Daniel Altmaier | 102 | 3 |
| ITA | Marco Cecchinato | 117 | 4 |
| ARG | Camilo Ugo Carabelli | 123 | 5 |
 KAZ | Timofey Skatov | 152 | 6 |
| ARG | Juan Manuel Cerúndolo | 155 | 7 |
| ITA | Franco Agamenone | 158 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Rémy Bertola 
Sumit Nagal Jakub Paul 
Daniel Rincón Fermín Tenti José Francisco Vidal Azorín Juan Manuel Cerúndolo def. Facundo Díaz Acosta 6–3, 3–6, 6–4. Franco Agamenone / Hernán Casanova def. 
Karol Drzewiecki / Jakub Paul 6–3, 6–4.
