| 2022 Knoxville Challenger | |
|---|---|
| Date | 7–13 November |
| Edition | 18th |
| Surface | Hard (Indoor) |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Ben Shelton | |
| Doubles | |
| Hunter Reese / Tennys Sandgren | |
The 2022 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Knoxville, United States between 7 and 13 November 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Michael Mmoh | 120 | 1 |
| USA | Stefan Kozlov | 132 | 2 |
| USA | Christopher Eubanks | 135 | 3 |
| USA | Ben Shelton | 156 | 4 |
| USA | Emilio Nava | 174 | 5 |
| USA | Aleksandar Kovacevic | 178 | 6 |
 FRA | Enzo Couacaud | 186 | 7 |
 CHN | Shang Juncheng | 195 | 8 |
The following players received wildcards into the singles main draw:
Blaise Bicknell Gage Brymer Martin Damm The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Alexander Bernard
Giles Hussey Cannon Kingsley Strong Kirchheimer Tristan McCormick
Iñaki Montes de la Torre Ben Shelton def. Christopher Eubanks 6–3, 1–6, 7–6(7–4). Hunter Reese / Tennys Sandgren def. Martin Damm / Mitchell Krueger 6–7(4–7), 7–6(7–3), [10–5].The 2017 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the fourteenth edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Knoxville, United States between 7 and 12 November 2017.
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