| 2022 Cary Challenger | |
|---|---|
| Date | 12–18 September |
| Edition | 9th |
| Surface | Hard |
| Location | Cary, North Carolina, United States |
| Champions | |
| Singles | |
 Michael Mmoh | |
| Doubles | |
| Nathaniel Lammons / Jackson Withrow | |
The 2022 Cary Challenger was a professional tennis tournament being played on hard courts. It was the 9th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cary, North Carolina, United States between 12 and 18 September 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Denis Kudla | 96 | 1 |
 AUS | Jordan Thompson | 102 | 2 |
| USA | Stefan Kozlov | 111 | 3 |
 ARG | Juan Pablo Ficovich | 128 | 4 |
| ARG | Facundo Mena | 131 | 5 |
| AUS | Aleksandar Vukic | 132 | 6 |
| USA | Michael Mmoh | 155 | 7 |
 GER | Dominik Koepfer | 161 | 8 |
The following players received wildcards into the singles main draw:
Martin Damm Ryan Seggerman Braden ShickThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Michael Mmoh def. Dominik Koepfer 7–5, 6–3. Nathaniel Lammons / Jackson Withrow def. 
Treat Huey / John-Patrick Smith 7–5, 2–6, [10–5].
