| 2022 Meerbusch Challenger | |
|---|---|
| Date | 8–14 August |
| Edition | 9th |
| Surface | Clay |
| Location | Meerbusch, Germany |
| Champions | |
| Singles | |
 Bernabé Zapata Miralles | |
| Doubles | |
 David Pel /  Szymon Walków | |
The 2022 Rhein Asset Open was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Meerbusch, Germany, between 8 and 14 August 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ESP | Bernabé Zapata Miralles | 89 | 1 |
 ITA | Franco Agamenone | 108 | 2 |
 GER | Jan-Lennard Struff | 123 | 3 |
| GER | Yannick Hanfmann | 139 | 4 |
 AUT | Jurij Rodionov | 143 | 5 |
 FRA | Geoffrey Blancaneaux | 151 | 6 |
| GER | Mats Moraing | 152 | 7 |
| GER | Maximilian Marterer | 154 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Adrian Andreev Lucas Gerch Carlos López Montagud Max Hans Rehberg Clément Tabur 
Alexey Vatutin The following player received entry as a lucky loser:
Bernabé Zapata Miralles def. Dennis Novak 6–1, 6–2. David Pel / Szymon Walków def. Neil Oberleitner / Philipp Oswald 7–5, 6–1.
