| 2022 San Marcos Open Aguascalientes | |
|---|---|
| Date | 18–24 April |
| Edition | 1st |
| Surface | Clay |
| Location | Aguascalientes, Mexico |
| Champions | |
| Singles | |
 Marc-Andrea Hüsler | |
| Doubles | |
 Nicolás Barrientos /  Miguel Ángel Reyes-Varela | |
The 2022 San Marcos Open Aguascalientes was a professional tennis tournament played on clay courts. It was the 1st edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Aguascalientes, Mexico between 18 and 24 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 SVK | Andrej Martin | 133 | 1 |
 CHI | Nicolás Jarry | 134 | 2 |
| SUI | Marc-Andrea Hüsler | 140 | 3 |
 USA | Ernesto Escobedo | 143 | 4 |
 GBR | Jay Clarke | 170 | 5 |
 NED | Tim van Rijthoven | 184 | 6 |
 ITA | Federico Gaio | 186 | 7 |
 ARG | Juan Pablo Ficovich | 205 | 8 |
The following players received wildcards into the singles main draw:
Diego Balderas Rodrigo Pacheco Méndez 
Shang Juncheng The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Nicolás Barrientos 
Elmar Ejupovic
Adrián Menéndez Maceiras 
Shintaro Mochizuki 
Akira Santillan Matías ZukasThe following player received entry as a lucky loser:
Marc-Andrea Hüsler def. Juan Pablo Ficovich 6–4, 4–6, 6–3. Nicolás Barrientos / Miguel Ángel Reyes-Varela def. 
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