| 2022 Sarasota Open | |
|---|---|
| Date | 11–17 April |
| Edition | 12th |
| Surface | Clay (Green) |
| Location | Sarasota, Florida, United States |
| Champions | |
| Singles | |
 Daniel Elahi Galán | |
| Doubles | |
 Robert Galloway / Jackson Withrow | |
The 2022 Sarasota Open was a professional tennis tournament played on clay courts. It was the 12th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Sarasota, Florida, United States between 11 and 17 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Denis Kudla | 81 | 1 |
 AUS | |||
 CHI | Alejandro Tabilo | 100 | 3 |
| USA | Steve Johnson | 108 | 4 |
| COL | Daniel Elahi Galán | 121 | 5 |
 ARG | Juan Ignacio Londero | 131 | 6 |
| USA | Jack Sock | 138 | 7 |
| CHI | Tomás Barrios Vera | 144 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Daniel Elahi Galán def. Steve Johnson 7–6(9–7), 4–6, 6–1. Robert Galloway / Jackson Withrow def. 
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