| 2022 San Marino Open | |
|---|---|
| Date | 8–14 August |
| Edition | 29th |
| Location | City of San Marino, San Marino |
| Champions | |
| Singles | |
 Pavel Kotov | |
| Doubles | |
 Marco Bortolotti /  Sergio Martos Gornés | |
The 2022 San Marino Open was a professional tennis tournament played on clay courts. The 29th edition of the tournament, which was part of the 2022 ATP Challenger Tour, took place in City of San Marino, San Marino between 8 and 14 August 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ESP | Carlos Taberner | 107 | 1 |
| Pavel Kotov | 132 | 2 | |
| ITA | Giulio Zeppieri | 136 | 3 |
| ITA | Flavio Cobolli | 138 | 4 |
| ITA | Marco Cecchinato | 140 | 5 |
 FRA | Alexandre Müller | 157 | 6 |
 CRO | Nino Serdarušić | 180 | 7 |
| ITA | Matteo Arnaldi | 215 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Viktor Durasovic Francesco Forti 
Lukas Neumayer 
Oleg Prihodko 
Valentin Vacherot Alexander Weis Pavel Kotov def. Matteo Arnaldi 7–6(7–5), 6–4. Marco Bortolotti / Sergio Martos Gornés def. 
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