| 2022 Ambato La Gran Ciudad | |
|---|---|
| Date | 17–23 October |
| Edition | 2nd |
| Surface | Clay |
| Location | Ambato, Ecuador |
| Champions | |
| Singles | |
 Facundo Bagnis | |
| Doubles | |
| Santiago Rodríguez Taverna / Thiago Agustín Tirante | |
The 2022 Ambato La Gran Ciudad was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Ambato, Ecuador between 17 and 23 October 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 PER | Juan Pablo Varillas | 104 | 1 |
| ARG | Facundo Bagnis | 112 | 2 |
| ARG | Juan Pablo Ficovich | 144 | 3 |
| ARG | Facundo Mena | 159 | 4 |
| ARG | Santiago Rodríguez Taverna | 169 | 5 |
 AUT | Gerald Melzer | 222 | 6 |
 SRB | Miljan Zekić | 242 | 7 |
| ARG | Thiago Agustín Tirante | 243 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
Sean Cuenin Arklon Huertas del Pino The following players received entry from the qualifying draw:
Sriram Balaji Conner Huertas del Pino 
Kosuke Ogura
Kiranpal Pannu Jorge Panta Matías Zukas Facundo Bagnis def. 
João Lucas Reis da Silva 7–6(9–7), 6–4. Santiago Rodríguez Taverna / Thiago Agustín Tirante def. 
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