| 2022 Cassis Open Provence | |
|---|---|
| Date | 5–11 September |
| Edition | 4th |
| Surface | Hard |
| Location | Cassis, France |
| Champions | |
| Singles | |
 Hugo Grenier | |
| Doubles | |
 Michael Geerts / Joran Vliegen | |
The 2022 Cassis Open Provence was a professional tennis tournament played on hard courts. It was the 4th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cassis, France between 5 and 11 September 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| FRA | Constant Lestienne | 75 | 1 |
 AUS | James Duckworth | 83 | 2 |
| FRA | Hugo Grenier | 119 | 3 |
 CZE | Tomáš Macháč | 126 | 4 |
 GER | Jan-Lennard Struff | 135 | 5 |
 GBR | Ryan Peniston | 140 | 6 |
 HUN | Zsombor Piros | 158 | 7 |
 JPN | Kaichi Uchida | 168 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Hugo Grenier def. James Duckworth 7–5, 6–4. Michael Geerts / Joran Vliegen def. 
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