| 2022 IBG Prague Open | |
|---|---|
| Date | 22–28 August |
| Category | ATP Challenger Tour |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | Prague, Czech Republic |
| Champions | |
| Singles | |
 Oleksii Krutykh | |
| Doubles | |
 Victor Vlad Cornea /  Andrew Paulson | |
The 2022 IBG Prague Open was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Prague, Czech Republic between 22 and 28 August 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ITA | Matteo Gigante | 266 | 1 |
| UKR | Oleksii Krutykh | 270 | 2 |
| UKR | Vitaliy Sachko | 271 | 3 |
 ESP | Oriol Roca Batalla | 272 | 4 |
 GER | Henri Squire | 287 | 5 |
 TUR | Ergi Kırkın | 303 | 6 |
| TUR | Cem İlkel | 304 | 7 |
 USA | Nicolas Moreno de Alboran | 318 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Oleksii Krutykh def. Lucas Gerch 6–3, 6–7(2–7), 6–2. Victor Vlad Cornea / Andrew Paulson def. 
Adrian Andreev / 
Murkel Dellien 6–3, 6–1.
