| 2022 Sparkassen ATP Challenger | |
|---|---|
| Date | 24–30 October |
| Edition | 13th |
| Surface | Hard (indoor) |
| Location | Ortisei, Italy |
| Champions | |
| Singles | |
 Borna Gojo | |
| Doubles | |
 Denis Istomin /  Evgeny Karlovskiy | |
The 2022 Sparkassen ATP Challenger was a professional tennis tournament played on indoor hard courts in Ortisei, Italy between 24 and 30 October 2022. It was the 13th edition of the tournament and was part of the 2022 ATP Challenger Tour.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CZE | Tomáš Macháč | 112 | 1 |
 CHI | Nicolás Jarry | 118 | 2 |
 GER | Yannick Hanfmann | 155 | 3 |
 ITA | Giulio Zeppieri | 166 | 4 |
| ITA | Flavio Cobolli | 167 | 5 |
 SVK | Lukáš Klein | 170 | 6 |
 HUN | Fábián Marozsán | 174 | 7 |
| GER | Daniel Masur | 179 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Térence Atmane Alibek Kachmazov Evgeny Karlovskiy 
Sandro Kopp Petr Nouza Andrew Paulson The following player received entry as a lucky loser:
Borna Gojo def. Lukáš Klein 7–6(7–4), 6–3. Denis Istomin / Evgeny Karlovskiy def. Marco Bortolotti / 
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