| 2022 Open de Oeiras III | |
|---|---|
| Date | 20–26 June |
| Edition | 7th |
| Surface | Clay |
| Location | Oeiras, Portugal |
| Champions | |
| Singles | |
 Kaichi Uchida | |
| Doubles | |
 Sadio Doumbia / Fabien Reboul | |
The 2022 Open de Oeiras III was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Oeiras, Portugal between 20 and 26 June 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 ESP | Roberto Carballés Baena | 91 | 1 |
 ARG | Facundo Bagnis | 108 | 2 |
 CHI | Nicolás Jarry | 136 | 3 |
 BRA | Daniel Dutra da Silva | 236 | 4 |
| Evgeny Karlovskiy | 250 | 5 | |
| JPN | Kaichi Uchida | 258 | 6 |
 SUI | Johan Nikles | 260 | 7 |
| FRA | Laurent Lokoli | 268 | 8 |
The following players received wildcards into the singles main draw:
Pedro Araújo Tiago Cação João Domingues The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Thomaz Bellucci Pedro Boscardin Dias 
Lucas Gerch Oscar José Gutierrez
Alexandar Lazarov 
Alex Rybakov Kaichi Uchida def. 
Kimmer Coppejans 6–2, 6–4. Sadio Doumbia / Fabien Reboul def. Robert Galloway / Alex Lawson 6–3, 3–6, [15–13].