| 2022 Open Harmonie mutuelle | |
|---|---|
| Date | 28 March–4 April |
| Edition | 17th |
| Surface | Hard (indoor) |
| Location | Saint-Brieuc, France |
| Champions | |
| Singles | |
 Jack Draper | |
| Doubles | |
 Sander Arends / David Pel | |
The 2022 Open Harmonie mutuelle was a professional tennis tournament played on hard courts. It was the seventeenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Brieuc, France between 28 March and 4 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 LTU | |||
 FRA | Quentin Halys | 115 | 2 |
| FRA | Gilles Simon | 139 | 3 |
| Roman Safiullin | 143 | 4 | |
| GBR | Jack Draper | 146 | 5 |
| FRA | Grégoire Barrère | 178 | 6 |
| FRA | Constant Lestienne | 205 | 7 |
| FRA | Antoine Hoang | 214 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Jack Draper def. 
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