| Singles | |
|---|---|
| 2023 Santa Cruz Challenger | |
| Champion |  Mariano Navone |
| Runner-up | Francisco Comesaña |
| Score | 4–6, 7–5, 6–1 |
Paul Jubb was the defending champion [1] but chose not to defend his title.
Mariano Navone won the title after defeating Francisco Comesaña 4–6, 7–5, 6–1 in the final.
Juan Manuel Cerúndolo (semifinals, retired) Genaro Alberto Olivieri (quarterfinals)
Hugo Dellien (first round) Thiago Agustín Tirante (quarterfinals, retired) Francisco Comesaña (final) Mariano Navone (champion)
Luciano Darderi (first round) Camilo Ugo Carabelli (second round)| Semifinals | Final | ||||||||||||
| 1 | Juan Manuel Cerúndolo | 4 | 0r | ||||||||||
| 6 | Mariano Navone | 6 | 3 | ||||||||||
| 6 | Mariano Navone | 4 | 7 | 6 | |||||||||
| 5 | Francisco Comesaña | 6 | 5 | 1 | |||||||||
| Andrea Collarini | 7 | 4 | 4 | ||||||||||
| 5 | Francisco Comesaña | 5 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | JM Cerúndolo | 6 | 6 | ||||||||||||||||||||||||
| Alex Barrena | 2 | 3 | 1 | JM Cerúndolo | 77 | 4 | 78 | ||||||||||||||||||||
| Q |  O Luz | 7 | 6 | Q | O Luz | 62 | 6 | 66 | |||||||||||||||||||
 B Kuzuhara | 5 | 2 | 1 | JM Cerúndolo | 7 | 6 | |||||||||||||||||||||
| T Boyer | 4 | 4 | PR | P Sakamoto | 5 | 4 | |||||||||||||||||||||
| PR | P Sakamoto | 6 | 6 | PR | P Sakamoto | 4 | 77 | 6 | |||||||||||||||||||
| JL Reis da Silva | 6 | 6 | JL Reis da Silva | 6 | 64 | 2 | |||||||||||||||||||||
| 7 | L Darderi | 4 | 3 | 1 | JM Cerúndolo | 4 | 0r | ||||||||||||||||||||
| 4 | TA Tirante | 2 | 6 | 2 | 6 | M Navone | 6 | 3 | |||||||||||||||||||
| D Dutra da Silva | 6 | 3 | 0r | 4 | TA Tirante | 77 | 77 | ||||||||||||||||||||
| M Pucinelli de Almeida | 6 | 6 | M Pucinelli de Almeida | 61 | 63 | ||||||||||||||||||||||
| Q | M Zormann | 4 | 4 | 4 | TA Tirante | 1 | 1r | ||||||||||||||||||||
| WC | JC Prado Ángelo | 6 | 6 | 6 | M Navone | 6 | 4 | ||||||||||||||||||||
 AD Vallejo | 3 | 1 | WC | JC Prado Ángelo | 3 | 3 | |||||||||||||||||||||
| WC |  M Soto | 7 | 64 | 1 | 6 | M Navone | 6 | 6 | |||||||||||||||||||
| 6 | M Navone | 5 | 77 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | C Ugo Carabelli | 6 | 6 | ||||||||||||||||||||||||
| M Dellien | 2 | 4 | 8 | C Ugo Carabelli | 4 | 5 | |||||||||||||||||||||
| Q | F Mena | 6 | 6 | Q | F Mena | 6 | 7 | ||||||||||||||||||||
| Q | P Boscardin Dias | 4 | 4 | Q | F Mena | 3 | 66 | ||||||||||||||||||||
| WC | JI Londero | 77 | 6 | A Collarini | 6 | 78 | |||||||||||||||||||||
| R Olivo | 64 | 2 | WC | JI Londero | |||||||||||||||||||||||
| A Collarini | 77 | 6 | A Collarini | w/o | |||||||||||||||||||||||
| 3 | H Dellien | 64 | 4 | A Collarini | 7 | 4 | 4 | ||||||||||||||||||||
| 5 | F Comesaña | 6 | 6 | 5 | F Comesaña | 5 | 6 | 6 | |||||||||||||||||||
| E Ribeiro | 2 | 4 | 5 | F Comesaña | 6 | 7 | |||||||||||||||||||||
 D Jordà Sanchis | 0 | 6 | 5 | G Heide | 3 | 5 | |||||||||||||||||||||
| G Heide | 6 | 3 | 7 | 5 | F Comesaña | 6 | 6 | ||||||||||||||||||||
| Q | G Villanueva | 77 | 6 | 2 | GA Olivieri | 4 | 1 | ||||||||||||||||||||
| Q | J Pereira | 64 | 2 | Q | G Villanueva | 4 | 6 | 1 | |||||||||||||||||||
| RA Burruchaga | 6 | 63 | 2 | 2 | GA Olivieri | 6 | 3 | 6 | |||||||||||||||||||
| 2 | GA Olivieri | 1 | 77 | 6 | |||||||||||||||||||||||
Máximo González was the defending champion when the event was last held in 2015, but he chose not to defend his title.
This was the first edition of the tournament. The tournament was originally scheduled to be played in Villa Allende but was relocated to Buenos Aires due to operational issues at the venue in Villa Allende.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.
Kaichi Uchida was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Igor Marcondes was the defending champion but chose not to defend his title.
Francisco Comesaña was the defending champion but lost in the second round to Andrea Collarini.
Arthur Rinderknech was the defending champion but chose not to defend his title.
This was the first edition of the tournament.
Jiří Lehečka was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion but lost in the quarterfinals to Luciano Darderi.
Mariano Navone was the defending champion and successfully defended his title after defeating Andrea Pellegrino 3–6, 6–2, 6–3 in the final.
Agustín Velotti was the defending champion from when the tournament was last held in 2016 but didn't defend his title as he retired from professional tennis.
Álvaro Guillén Meza was the defending champion but lost in the second round to Mariano Navone.
Gonzalo Bueno was the defending champion but lost in the first round to Mariano Navone.
Thiago Monteiro was the defending champion but lost in the quarterfinals to Román Andrés Burruchaga.
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Sebastián Báez defeated Mariano Navone in the final, 6–2, 6–1 to win the singles tennis title at the 2024 Rio Open. It was his fifth ATP Tour title and his first ATP 500 title. Navone was the second qualifier to contest the Rio Open final, following Gianluca Mager in 2020.
Sebastián Báez defeated Alejandro Tabilo in the final, 3–6, 6–0, 6–4 to win the singles tennis title at the 2024 Chile Open. It was his sixth career ATP Tour title and his second title in as many weeks, having won the Rio Open the week before.
Mariano Navone was the defending champion but chose not to defend his title.