| 2023 Santa Cruz Challenger | |
|---|---|
| Date | 11–17 September |
| Edition | 3rd |
| Surface | Clay |
| Location | Santa Cruz de la Sierra, Bolivia |
| Champions | |
| Singles | |
 Mariano Navone | |
| Doubles | |
 Boris Arias / Federico Zeballos | |
The 2023 Santa Cruz Challenger was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 11 and 17 September 2023.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Juan Manuel Cerúndolo | 93 | 1 |
| ARG | Genaro Alberto Olivieri | 140 | 2 |
| BOL | Hugo Dellien | 147 | 3 |
| ARG | Thiago Agustín Tirante | 150 | 4 |
| ARG | Francisco Comesaña | 160 | 5 |
| ARG | Mariano Navone | 184 | 6 |
 ITA | Luciano Darderi | 185 | 7 |
| ARG | Camilo Ugo Carabelli | 202 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Mariano Navone def. Francisco Comesaña 4–6, 7–5, 6–1. Boris Arias / Federico Zeballos def. 
Matías Soto / Gonzalo Villanueva 6–2, 4–6, [10–7].The 2013 Copa San Juan Gobierno was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2013 ATP Challenger Tour. It took place in San Juan, Argentina between 7 and 13 October 2013.
The 2018 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 12 and 18 November 2018.
The 2019 Punta Open was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Punta del Este, Uruguay between 21 and 27 January 2019.
The 2019 Morelos Open was a professional tennis tournament played on outdoor hard courts. It was the sixth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Cuernavaca, Mexico between 18–24 February 2019.
The 2019 Challenger ATP Cachantún Cup was a professional tennis tournament played on red clay courts. It was the 12th edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Santiago, Chile between 4 and 10 March 2019.
The 2021 Challenger de Santiago III was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Santiago, Chile between 11 and 17 October 2021.
The 2021 São Paulo Challenger de Tênis was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in São Paulo, Brazil between 29 November and 5 December 2021.
The 2021 Florianópolis Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Florianópolis, Brazil from 6 to 12 December 2021.
The 2022 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 26 September and 2 October 2022.
The 2022 Santa Cruz Challenger, also known as Dove MEN + CARE Challenger Bolivia, was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 24 and 30 January 2022.
The 2022 Santa Cruz Challenger II, also known as Dove MEN + CARE Bolivia Open to differentiate it from the previous edition played the same year, was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santa Cruz de la Sierra, Bolivia between 21 and 27 March 2022.
The 2022 Salvador Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Salvador, Brazil between 2 and 8 May 2022.
The 2022 Open Bogotá was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Bogotá, Colombia between 4 and 10 July 2022.
The 2022 República Dominicana Open was a professional tennis tournament played on green clay courts. It was the sixth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santo Domingo, Dominican Republic between 15 and 21 August 2022.
The 2023 Challenger Concepción was a professional tennis tournament played on clay courts. It was the third edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Concepción, Chile between 24 and 29 January 2023.
The 2023 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 17th edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santiago, Chile between 6 and 12 March 2023.
The 2023 Challenger AAT was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 24 and 30 April 2023.
The 2023 Cali Open was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Cali, Colombia between 19 and 24 June 2023.
The 2023 Open Rionegro was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Medellín, Colombia between 26 June and 1 July 2023.
The 2023 Challenger Santa Fe was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santa Fe, Argentina between 3 and 9 July 2023.
