| Singles | |
|---|---|
| 2024 Challenger Santa Fe | |
| Champion |  Andrea Collarini |
| Runner-up | Facundo Mena |
| Score | 6–2, 6–3 |
Mariano Navone was the defending champion [1] but chose not to defend his title.
Andrea Collarini won the title after defeating Facundo Mena 6–2, 6–3 in the final.
Hugo Dellien (second round, retired) Murkel Dellien (first round) Santiago Rodríguez Taverna (first round)
Hady Habib (first round)
Gonzalo Bueno (second round)
Álvaro Guillén Meza (first round) Andrea Collarini (champion)
Pedro Sakamoto (first round)| Semifinals | Final | ||||||||||||
| 7 | Andrea Collarini | 7 | 6 | ||||||||||
| Gonzalo Villanueva | 5 | 3 | |||||||||||
| 7 | Andrea Collarini | 6 | 6 | ||||||||||
| Facundo Mena | 2 | 3 | |||||||||||
| Facundo Mena | 77 | 77 | |||||||||||
 Ulises Blanch | 63 | 65 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | H Dellien | 6 | 6 | ||||||||||||||||||||||||
| Alt | Wilson Leite | 4 | 4 | 1 | H Dellien | 2r | |||||||||||||||||||||
| H Casanova | 2 | 1 | M Pucinelli de Almeida | 5 | |||||||||||||||||||||||
| M Pucinelli de Almeida | 6 | 6 | M Pucinelli de Almeida | 7 | 2 | 3 | |||||||||||||||||||||
| Lorenzo Joaquín Rodríguez | 1 | 1 | 7 | A Collarini | 5 | 6 | 6 | ||||||||||||||||||||
| JB Torres | 6 | 6 | JB Torres | 3 | 1 | ||||||||||||||||||||||
| WC | AL Lingua Lavallén | 1 | 61 | 7 | A Collarini | 6 | 6 | ||||||||||||||||||||
| 7 | A Collarini | 6 | 77 | 7 | A Collarini | 7 | 6 | ||||||||||||||||||||
| 4 | H Habib | 5 | 65 | G Villanueva | 5 | 3 | |||||||||||||||||||||
| Alt |  Diego Augusto Barreto Sánchez | 7 | 77 | Alt | DA Barreto Sánchez | 4 | 3 | ||||||||||||||||||||
| V Aboian | 2 | 3 | Q | T Farjat | 6 | 6 | |||||||||||||||||||||
| Q | Tomás Farjat | 6 | 6 | Q | T Farjat | 7 | 5 | 4 | |||||||||||||||||||
| G Villanueva | 6 | 6 | G Villanueva | 5 | 7 | 6 | |||||||||||||||||||||
| WC | Juan Estévez | 1 | 3 | G Villanueva | 6 | 6 | |||||||||||||||||||||
| WC | Ezequiel Monferrer | 7 | 2 | 6 | WC | E Monferrer | 4 | 4 | |||||||||||||||||||
| 6 | Á Guillén Meza | 5 | 6 | 3 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | G Bueno | 711 | 6 | ||||||||||||||||||||||||
| Q | Dali Blanch | 69 | 3 | 5 | G Bueno | 7 | 4 | 1 | |||||||||||||||||||
| Q | Leonardo Aboian | 6 | 3 | 64 | Q | T Hilderbrand | 5 | 6 | 6 | ||||||||||||||||||
| Q | T Hilderbrand | 3 | 6 | 77 | Q | T Hilderbrand | 4 | 63 | |||||||||||||||||||
| F Mena | 5 | 6 | 7 | F Mena | 6 | 77 | |||||||||||||||||||||
| Q | E Gómez | 7 | 3 | 5 | F Mena | 77 | 6 | ||||||||||||||||||||
| Guido Iván Justo | 6 | 7 | GI Justo | 62 | 2 | ||||||||||||||||||||||
| 3 | S Rodríguez Taverna | 3 | 5 | F Mena | 77 | 77 | |||||||||||||||||||||
| 8 | P Sakamoto | 2 | 6 | 5 | U Blanch | 63 | 65 | ||||||||||||||||||||
| Lautaro Midón | 6 | 4 | 7 | L Midón | 6 | 6 | |||||||||||||||||||||
| PR | N Álvarez | 6 | 3 | 3 | N Zanellato | 2 | 2 | ||||||||||||||||||||
| Nicolas Zanellato | 4 | 6 | 6 | L Midón | 4 | 4 | |||||||||||||||||||||
| P Boscardin Dias | 4 | 6 | 6 | U Blanch | 6 | 6 | |||||||||||||||||||||
| Q |  Aleksandr Lobanov | 6 | 3 | 1 | P Boscardin Dias | 4 | 4 | ||||||||||||||||||||
| U Blanch | 6 | 6 | U Blanch | 6 | 6 | ||||||||||||||||||||||
| 2 | M Dellien | 4 | 3 | ||||||||||||||||||||||||
Guido Andreozzi was the defending champion but lost in the second round to Emilio Gómez.
Pablo Andújar was the defending champion but chose not to defend his title.
Cristian Garín was the defending champion but chose not to defend his title.
Cristian Garín was the defending champion but chose not to defend his title.
Guido Pella was the defending champion but chose not to defend his title.
Fabio Fognini was the champion in 2014, when the event was last held, but chose to compete in Dubai instead.
Andrea Collarini was the defending champion but lost in the first round to Marco Cecchinato.
Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
This was the first edition of the tournament.
Conner Huertas del Pino and Mats Rosenkranz were the defending champions but only Huertas del Pino chose to defend his title, partnering Alexander Merino. Huertas del Pino lost in the first round to Murkel Dellien and Jorge Panta.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.
Francisco Comesaña was the defending champion but lost in the second round to Andrea Collarini.
Paul Jubb was the defending champion but chose not to defend his title.
Agustín Velotti was the defending champion from when the tournament was last held in 2016 but didn't defend his title as he retired from professional tennis.
Álvaro Guillén Meza was the defending champion but lost in the second round to Mariano Navone.
Gonzalo Bueno was the defending champion but lost in the first round to Mariano Navone.
Facundo Díaz Acosta defeated Nicolás Jarry in the final, 6–3, 6–4 to win the singles tennis title at the 2024 Argentina Open. He did not lose a set en route to his first ATP Tour title and became the first wildcard to win the Argentina Open, as well as the first unseeded player to win the title since Alexandr Dolgopolov in 2017.
Mariano Navone was the defending champion but chose not to defend his title.
Boris Arias and Federico Zeballos were the defending champions but lost in the quarterfinals to Hugo and Murkel Dellien.