| Singles | |
|---|---|
| 2024 Santa Cruz Challenger II | |
| 2024 Champion |  Camilo Ugo Carabelli |
Camilo Ugo Carabelli was the defending champion [1] but chose not to defend his title.
| Singles | |
|---|---|
| 2024 Santa Cruz Challenger II | |
| 2024 Champion | Camilo Ugo Carabelli |
Camilo Ugo Carabelli was the defending champion [1] but chose not to defend his title.
Juan Manuel Cerúndolo 
Murkel Dellien (second round) Andrea Collarini (second round, retired)
Hady Habib (semifinals)
Álvaro Guillén Meza 
Pedro Sakamoto (quarterfinals) Renzo Olivo (second round) Facundo Mena (semifinals)| Semifinals | Final | ||||||||||||
| 1 | Juan Manuel Cerúndolo | 77 | 6 | ||||||||||
| 4 | Hady Habib | 64 | 4 | ||||||||||
| 1 | Juan Manuel Cerúndolo | ||||||||||||
| 5 | Álvaro Guillén Meza | ||||||||||||
| 8 | Facundo Mena | 6 | 3 | 3 | |||||||||
| 5 | Álvaro Guillén Meza | 3 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | JM Cerúndolo | 1 | 6 | 7 | |||||||||||||||||||||||
| Lautaro Midón | 6 | 1 | 5 | 1 | JM Cerúndolo | 6 | 7 | ||||||||||||||||||||
| SE | P Boscardin Dias | 4 | 2 | Q | J Pereira | 4 | 5 | ||||||||||||||||||||
| Q | J Pereira | 6 | 6 | 1 | JM Cerúndolo | 6 | 6 | ||||||||||||||||||||
| H Casanova | 6 | 6 | 6 | P Sakamoto | 4 | 3 | |||||||||||||||||||||
| JL Reis da Silva | 2 | 2 | H Casanova | 3 | 77 | 63 | |||||||||||||||||||||
| V Aboian | 65 | 78 | 4 | 6 | P Sakamoto | 6 | 63 | 77 | |||||||||||||||||||
| 6 | P Sakamoto | 77 | 66 | 6 | 1 | JM Cerúndolo | 77 | 6 | |||||||||||||||||||
| 4 | H Habib | 6 | 77 | 4 | H Habib | 64 | 4 | ||||||||||||||||||||
| M Pucinelli de Almeida | 3 | 64 | 4 | H Habib | 77 | 7 | |||||||||||||||||||||
| Q |  Noah Schachter | 6 | 3 | 3 |  M Soto | 62 | 5 | ||||||||||||||||||||
| M Soto | 3 | 6 | 6 | 4 | H Habib | 77 | 4 | 7 | |||||||||||||||||||
| Q | Dali Blanch | 6 | 4 | 3 | JC Prado Ángelo | 63 | 6 | 5 | |||||||||||||||||||
| JC Prado Ángelo | 4 | 6 | 6 | JC Prado Ángelo | 6 | 3 | 6 | ||||||||||||||||||||
| WC | Agustín Eduardo Cuéllar Lorberg | 2 | 2 | 7 | R Olivo | 2 | 6 | 3 | |||||||||||||||||||
| 7 | R Olivo | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | F Mena | 78 | 6 | ||||||||||||||||||||||||
| Alt | Nicolas Zanellato | 66 | 1 | 8 | F Mena | 6 | 7 | ||||||||||||||||||||
| G Villanueva | 4 | 2 | AL Lingua Lavallén | 2 | 5 | ||||||||||||||||||||||
| AL Lingua Lavallén | 6 | 6 | 8 | F Mena | 6 | 6 | |||||||||||||||||||||
| LL | U Blanch | 65 | 4 | Q | L Aboian | 3 | 2 | ||||||||||||||||||||
| Q | Leonardo Aboian | 77 | 6 | Q | L Aboian | 6 | 1 | ||||||||||||||||||||
| WC | E Gómez | 2 | 5 | 3 | A Collarini | 3 | 2r | ||||||||||||||||||||
| 3 | A Collarini | 6 | 7 | 8 | F Mena | 6 | 3 | 3 | |||||||||||||||||||
| 5 | Á Guillén Meza | 77 | 6 | 5 | Á Guillén Meza | 3 | 6 | 6 | |||||||||||||||||||
| Alt |  Adrià Soriano Barrera | 65 | 3 | 5 | Á Guillén Meza | 7 | 62 | 6 | |||||||||||||||||||
| Q | Guido Iván Justo | 5 | 1 | JB Torres | 5 | 77 | 1 | ||||||||||||||||||||
| JB Torres | 7 | 6 | 5 | Á Guillén Meza | 6 | 4 | 6 | ||||||||||||||||||||
| WC | Raúl García | 4 | 1 | G Johns | 2 | 6 | 3 | ||||||||||||||||||||
| Garrett Johns | 6 | 6 | G Johns | 0 | 6 | 77 | |||||||||||||||||||||
| Q |  Diego Augusto Barreto Sánchez | 1 | 0 | 2 | M Dellien | 6 | 4 | 64 | |||||||||||||||||||
| 2 | M Dellien | 6 | 6 | ||||||||||||||||||||||||
Gastão Elias was the defending champion but lost in the first round to Camilo Ugo Carabelli.
Daniel Elahi Galán was the defending champion, but chose not to defend his title.
Sebastián Báez was the defending champion but chose not to defend his title.
This was the first edition of the tournament as part of the Legión Sudamericana.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.
Emilio Gómez was the defending champion and successfully defended his title, defeating Nicolas Moreno de Alboran 6–7(2–7), 7–6(7–4), 7–5 in the final.
Santiago Rodríguez Taverna was the defending champion but lost in the quarterfinals to Genaro Alberto Olivieri.
Pedro Sousa was the defending champion but chose not to defend his title.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Nicolás Jarry was the defending champion but chose not to defend his title.
Sergio Galdós and Gonçalo Oliveira were the defending champions but only Galdós chose to defend his title, partnering Renzo Olivo. Galdós lost in the semifinals to Orlando Luz and Camilo Ugo Carabelli.
Juan Pablo Varillas was the defending champion but lost in the first round to Thiago Agustín Tirante.
Facundo Díaz Acosta was the defending champion but lost in the final to Juan Manuel Cerúndolo.
Camilo Ugo Carabelli was the defending champion but lost in the second round to Giovanni Mpetshi Perricard.
Hugo Dellien was the defending champion but chose not to defend his title.
Camilo Ugo Carabelli was the defending champion but chose not to defend his title.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Mariano Navone was the defending champion but chose not to defend his title.
Alexander Shevchenko was the defending champion but chose not to defend his title.