AAMDC

Last updated June 01, 2025

The AAMDC gene encodes an AMDC or Adipogenesis Associated Mth938 Domain Containing protein that is integral to various cellular processes. The protein is involved in lipid metabolism, specifically adipogenesis, and plays a role in signal transduction as an oncoprotein.^[1]

The AAMDC protein is found in both the cytoplasmic and nuclear compartments of the cell.^[2]

References

↑ Xiao, Rong; Li, Chengping; Wang, Chao; Cao, Yang; Zhang, Lichun; Guo, Yan; Xin, Youzhi; Zhang, Haiyan; Zhou, Guoli (July 2019). "Adipogenesis associated Mth938 domain containing (AAMDC) protein expression is regulated by alternative polyadenylation and microRNAs". FEBS Letters. 593 (14): 1724–1734. doi: 10.1002/1873-3468.13449 . ISSN 1873-3468. PMID 31116411.
↑ Golden, Emily; Rashwan, Rabab; Woodward, Eleanor A.; Sgro, Agustin; Wang, Edina; Sorolla, Anabel; Waryah, Charlene; Tie, Wan Jun; Cuyàs, Elisabet; Ratajska, Magdalena; Kardaś, Iwona; Kozlowski, Piotr; Johnstone, Elizabeth K. M.; See, Heng B.; Duffy, Ciara (2021-03-26). "The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer". Nature Communications. 12 (1): 1920. Bibcode:2021NatCo..12.1920G. doi: 10.1038/s41467-021-22101-7 . hdl: 11343/277935 . ISSN 2041-1723. PMC 7998036 . PMID 33772001.

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[1] Xiao, Rong; Li, Chengping; Wang, Chao; Cao, Yang; Zhang, Lichun; Guo, Yan; Xin, Youzhi; Zhang, Haiyan; Zhou, Guoli (July 2019). "Adipogenesis associated Mth938 domain containing (AAMDC) protein expression is regulated by alternative polyadenylation and microRNAs". FEBS Letters. 593 (14): 1724–1734. doi: 10.1002/1873-3468.13449 . ISSN 1873-3468. PMID 31116411.

[2] Golden, Emily; Rashwan, Rabab; Woodward, Eleanor A.; Sgro, Agustin; Wang, Edina; Sorolla, Anabel; Waryah, Charlene; Tie, Wan Jun; Cuyàs, Elisabet; Ratajska, Magdalena; Kardaś, Iwona; Kozlowski, Piotr; Johnstone, Elizabeth K. M.; See, Heng B.; Duffy, Ciara (2021-03-26). "The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer". Nature Communications. 12 (1): 1920. Bibcode:2021NatCo..12.1920G. doi: 10.1038/s41467-021-22101-7 . hdl: 11343/277935 . ISSN 2041-1723. PMC 7998036 . PMID 33772001.

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