ASTE1

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Asteroid homolog 1 (Drosophila) is a protein that in humans is encoded by the ASTE1 gene. [1] The gene is also known as HT001. [1]

Contents

Model organisms

Model organisms have been used in the study of ASTE1 function. A conditional knockout mouse line, called Aste1tm1a(KOMP)Wtsi [6] [7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. [8] [9] [10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. [4] [11] Twenty four tests were carried out on homozygous mutant mice and one significant abnormality was observed: females had an increased susceptibility to bacterial infection. [4]

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References

  1. 1 2 "Asteroid homolog 1 (Drosophila)" . Retrieved 2011-12-06.
  2. "Salmonella infection data for Aste1". Wellcome Trust Sanger Institute.
  3. "Citrobacter infection data for Aste1". Wellcome Trust Sanger Institute.
  4. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID   85911512.
  5. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. "International Knockout Mouse Consortium".
  7. "Mouse Genome Informatics".
  8. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC   3572410 . PMID   21677750.
  9. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID   21677718.
  10. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID   17218247. S2CID   18872015.
  11. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC   3218837 . PMID   21722353.

Further reading