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The smallpox vaccine is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus. Cowpox served as a natural vaccine until the modern smallpox vaccine emerged in the 20th century. From 1958 to 1977, the World Health Organization (WHO) conducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Although routine smallpox vaccination is no longer performed on the general public, the vaccine is still being produced to guard against bioterrorism, biological warfare, and mpox.
Paul Francis Wehrle was a researcher and physician who helped develop of methods to prevent and treat polio and smallpox.
A jet injector is a type of medical injecting syringe device used for a method of drug delivery known as jet injection. A narrow, high-pressure stream of liquid is made to penetrate the outermost layer of the skin to deliver medication to targeted underlying tissues of the epidermis or dermis, fat, or muscle.
Frank John Fenner was an Australian scientist with a distinguished career in the field of virology. His two greatest achievements are cited as overseeing the eradication of smallpox, and the attempted control of Australia's rabbit plague through the introduction of Myxoma virus.
Donald Ainslie Henderson was an American medical doctor, educator, and epidemiologist who directed a 10-year international effort (1967–1977) that eradicated smallpox throughout the world and launched international childhood vaccination programs. From 1977 to 1990, he was Dean of the Johns Hopkins School of Public Health. Later, he played a leading role in instigating national programs for public health preparedness and response following biological attacks and national disasters. At the time of his death, he was Professor and Dean Emeritus of the Johns Hopkins Bloomberg School of Public Health, and Professor of Medicine and Public Health at the University of Pittsburgh, as well as Distinguished Scholar at the UPMC Center for Health Security.
William Herbert Foege is an American physician and epidemiologist who is credited with "devising the global strategy that led to the eradication of smallpox in the late 1970s". From May 1977 to 1983, Foege served as the Director of the Centers for Disease Control and Prevention.
Ali Maow Maalin was a Somali hospital cook and health worker from Merca who is the last person known to have been infected with naturally occurring Variola minor smallpox. He was diagnosed with the disease in October 1977 and made a full recovery. Although he had many contacts, none of them developed the disease, and an aggressive containment campaign was successful in preventing an outbreak. Smallpox was declared to have been eradicated globally by the World Health Organization (WHO) two years later. Maalin was subsequently involved in the successful poliomyelitis eradication campaign in Somalia, and he died of malaria while carrying out polio vaccinations after the re-emergence of the poliovirus in 2013.
Abram Salmon Benenson was an authority in public health, preventive medicine, military medicine, and "shoe-leather" epidemiology. He was best known as the editor-in-chief for the Control of Communicable Diseases Manual of the American Public Health Association. His tenure as editor was so lengthy that the manual was often known as the "Benenson Book".
Ponduri Venkata Ramana Rao was an Indian microbiologist. He was born at Rajupalem in Ongole district, Madras Presidency, British India.
Mass vaccination is a public policy effort to vaccinate a large number of people, possibly the entire population of the world or of a country or region, within a short period of time. This policy may be directed during a pandemic, when there is a localized outbreak or scare of a disease for which a vaccine exists, or when a new vaccine is invented.
Aaron Naparstek, is the founder of Streetsblog, a web site providing daily coverage of transportation, anti-automobile activism, land use and environmental issues in New York City. Since its founding in June 2006, Streetsblog has emerged as an influential forum for New York City's Livable Streets Movement, dedicated to reclaiming cities' public spaces from the automobile and improving conditions for pedestrians, cyclists and transit users. Streetsblog is published by OpenPlans.
Smallpox was an infectious disease caused by variola virus, which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date.
The 1974 smallpox epidemic in India infected 188,000 people, leading to the deaths of 31,000 Indians.
The history of smallpox extends into pre-history. Genetic evidence suggests that the smallpox virus emerged 3,000 to 4,000 years ago. Prior to that, similar ancestral viruses circulated, but possibly only in other mammals, and possibly with different symptoms. Only a few written reports dating from about 500 AD to 1000 AD are considered reliable historical descriptions of smallpox, so understanding of the disease prior to that has relied on genetics and archaeology. However, during the 2nd millennium AD, especially starting in the 16th century, reliable written reports become more common. The earliest physical evidence of smallpox is found in the Egyptian mummies of people who died some 3,000 years ago. Smallpox has had a major impact on world history, not least because indigenous populations of regions where smallpox was non-native, such as the Americas and Australia, were rapidly and greatly reduced by smallpox during periods of initial foreign contact, which helped pave the way for conquest and colonization. During the 18th century the disease killed an estimated 400,000 Europeans each year, including five reigning monarchs, and was responsible for a third of all blindness. Between 20 and 60% of all those infected—and over 80% of infected children—died from the disease.
The bifurcated needle is a narrow steel rod, approximately 5 cm (2 in) long with two prongs at one end. It was designed to hold one dose of reconstituted freeze-dried smallpox vaccine between its prongs. Up to one hundred vaccinations can be given from one vial of the reconstituted vaccine. The established technique for smallpox vaccination is to dip the needle in the vaccine, and then perpendicularly puncture a person's upper arm fifteen times rapidly in a small circular area. Though skin in the area should be clean, use of an alcohol swab is optional and if used the skin must be allowed to fully dry to avoid deactivation of the live virus vaccine. The punctures should remain in an area approximately 5 mm in diameter. The needle is then disposed of. When done correctly a trace of blood appears at the vaccination site within 10 to 20 seconds after the procedure.
Nicole Grasset was a Swiss-French medical virologist and microbiologist-epidemiologist. Grasset was the senior smallpox advisor for the South-East Asia Regional Office (SEARO) of the World Health Organization (WHO) from 1971 through the end of the WHO smallpox eradication campaign.
Donald R. Hopkins is a Bahamian American physician, a MacArthur Fellow and is the Vice President and Director of Health Programs at The Carter Center. He graduated from Morehouse College with a B.S., from the University of Chicago with a Doctor of Medicine, and from the Harvard School of Public Health with a Master of Public Health. He studied at the Institute of European Studies, University of Vienna.
Isao Arita was a Japanese physician, virologist and vaccination specialist who headed the World Health Organization (WHO) Smallpox Eradication Unit in 1977–85. During this period, smallpox became the first infectious disease of humans to be eradicated globally. For this work, he and his colleagues were awarded the Japan Prize in 1988. He also advised the successful programme to eradicate poliovirus from the Western Pacific region.
Israel Weinstein was an American physician and bacteriologist, best known for his work in public health in New York City, especially during the 1947 New York City smallpox outbreak as the Commissioner of Health of the City of New York from March 13, 1946, to November 3, 1947, under Mayor William O'Dwyer.
John Michael Lane was an American epidemiologist who was a director of the Epidemic Intelligence Service's Global Smallpox Eradication program from 1973 to 1981, and who played a leading role in the eradication of smallpox in 1977.
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