Abdul Waseh Basit

Last updated
Abdul W. Basit
Alma materUniversity of Bath (BPharm); The School of Pharmacy, University of London (PhD)
Known for3D printing of pharmaceuticals

Drug delivery

Gastroenterology
Scientific career
FieldsPharmaceutics
InstitutionsUniversity College London
Doctoral advisor John Michael Newton

Abdul Waseh Basit is a professor of pharmaceutics at University College London, [1] and founder of two pharmaceutical biotechnology companies spinning out of UCL. Basit is interested in particular in oral drug delivery and pharmaceutical three-dimensional (3D) printing. [2] [3] [4]

Contents

Education and career

Basit graduated with a first class honours degree in pharmacy in 1993 from the University of Bath and undertook his pharmacy pre-registration training at Pfizer Pharmaceuticals, becoming a registered pharmacist in 1994. [5] [6] He joined the School of Pharmacy, University of London (now UCL School of Pharmacy) in 1994 where he completed his PhD in pharmaceutics and was appointed professor in pharmaceutics in 2010.

Basit leads a research group based in University College London that investigates gastroenterology, [7] [8] metabolic potential of the gastrointestinal microbiota on drugs, [9] [10] and the development of modern pharmaceutical manufacturing techniques using three-dimensional (3D) printing. [11] [12] In 2016, Basit was appointed the European editor of the International Journal of Pharmaceutics. [13] His h-index is currently 68[ as of? ] with over 13,000 citations. [14]

In 2014, Basit founded FabRx with Simon Gaisford, Alvaro Goyanes Goyanes and Bill Lindsay spinning out from University College London. The firm is a biotechnology company that is developing 3D printing technology for medicines and medical devices. In 2017, FabRx was awarded the TCT Best Start-Up Award. [15] In 2019, it received over £600,000 from Innovate UK to develop a 3D printer for the production of personalised medicines. [16] In 2016, Basit co-founded Intract Pharma; the firm is a pharmaceutical company that provides licensable technologies for targeted delivery in the gastrointestinal tract. In 2018, it received £1.4 million from Innovate UK to develop a scalable manufacturing process for oral antibody products. [17] [18]

Awards and honours

Publications

Related Research Articles

An emulsion is a mixture of two or more liquids that are normally immiscible owing to liquid-liquid phase separation. Emulsions are part of a more general class of two-phase systems of matter called colloids. Although the terms colloid and emulsion are sometimes used interchangeably, emulsion should be used when both phases, dispersed and continuous, are liquids. In an emulsion, one liquid is dispersed in the other. Examples of emulsions include vinaigrettes, homogenized milk, liquid biomolecular condensates, and some cutting fluids for metal working.

<span class="mw-page-title-main">Route of administration</span> Path by which a drug, fluid, poison, or other substance is taken into the body

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<span class="mw-page-title-main">Selective laser sintering</span> 3D printing technique

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<span class="mw-page-title-main">Drug delivery</span> Methods for delivering drugs to target sites

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<span class="mw-page-title-main">Methacrylic anhydride</span> Chemical compound

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<span class="mw-page-title-main">Aldoxorubicin</span> Medication

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<span class="mw-page-title-main">Andreas Bernkop-Schnürch</span> Austrian university teacher (born 1965)

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<span class="mw-page-title-main">Applications of 3D printing</span>

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<span class="mw-page-title-main">Estradiol acetylsalicylate</span> Chemical compound

Estradiol acetylsalicylate, or estradiol 3-acetylsalicylate, is a synthetic estrogen and estrogen ester – specifically, the C3 acetylsalicylic acid (aspirin) ester of estradiol – which was described in the late 1980s and was never marketed. In dogs, the oral bioavailability of estradiol acetylsalicylate was found to be 17-fold higher than that of unmodified estradiol. However, a subsequent study found that the oral bioavailability of estradiol and estradiol acetylsalicylate did not differ significantly in rats, suggestive of a major species difference.

<span class="mw-page-title-main">Progesterone carboxymethyloxime</span> Chemical compound

Progesterone carboxymethyloxime, or progesterone 3-(O-carboxymethyl)oxime (P4-3-CMO), is a progestin which was never marketed. It is an oral prodrug of progesterone with improved pharmacokinetic properties. The compound was developed in an attempt to address the poor oral pharmacokinetics of progesterone, including its very low bioavailability and short biological half-life. These properties of progesterone are thought to be caused by its low water solubility and high metabolic clearance rate due to rapid degradation in the intestines and liver. Drugs with low aqueous solubility are not absorbed well in the intestines because their dissolution in water is limited.

In vivo supersaturation is the behavior of orally administered compounds that undergo supersaturation as they pass through the gastrointestinal (GI) tract. Typically these compounds have a weakly basic nature and a relatively low solubility in aqueous solutions. In vivo supersaturation is a recent phenomenon that was first observed by Yamashita et al. in 2003.

<span class="mw-page-title-main">Ijeoma Uchegbu</span> Nigerian-British pharmacist and Professor of Pharmacy

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References

  1. ↑ UCL (2018-04-25). "Professor Abdul Basit". UCL School of Pharmacy. Retrieved 2020-01-07.
  2. ↑ "Abdul Basit - Google Scholar Citations". scholar.google.co.uk. Retrieved 2020-01-07.
  3. ↑ "Abdul W Basit, Author at ONdrugDelivery". ONdrugDelivery. Retrieved 2020-01-07.
  4. ↑ "Abdul Basit". scholar.google.com. Retrieved 2020-10-14.
  5. ↑ "Professor Abdul Basit". www.ucl.ac.uk. 25 April 2018. Retrieved 2020-01-07.
  6. ↑ "Joint Pharmaceutical Analysis Group". www.jpag.org. Retrieved 2020-01-07.
  7. ↑ McConnell, Emma L; Basit, Abdul W; Murdan, Sudaxshina (2008-01-01). "Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments". Journal of Pharmacy and Pharmacology. 60 (1): 63–70. doi: 10.1211/jpp.60.1.0008 . ISSN   0022-3573. PMID   18088506. S2CID   12647907.
  8. ↑ McConnell, Emma L.; Fadda, Hala M.; Basit, Abdul W. (2008-12-08). "Gut instincts: Explorations in intestinal physiology and drug delivery". International Journal of Pharmaceutics. 364 (2): 213–226. doi:10.1016/j.ijpharm.2008.05.012. ISSN   0378-5173. PMID   18602774.
  9. ↑ Sousa, Tiago; Paterson, Ronnie; Moore, Vanessa; Carlsson, Anders; Abrahamsson, Bertil; Basit, Abdul W. (2008-11-03). "The gastrointestinal microbiota as a site for the biotransformation of drugs". International Journal of Pharmaceutics. 363 (1): 1–25. doi:10.1016/j.ijpharm.2008.07.009. ISSN   0378-5173. PMID   18682282.
  10. ↑ Wilson, Peter J; Basit, Abdul W (2005-08-26). "Exploiting gastrointestinal bacteria to target drugs to the colon: An in vitro study using amylose coated tablets". International Journal of Pharmaceutics. Festschrift in Honour of the 65th Birthday of Professor A.T. Florence. 300 (1): 89–94. doi:10.1016/j.ijpharm.2005.05.010. ISSN   0378-5173. PMID   16023805.
  11. ↑ Goyanes, Alvaro; Buanz, Asma B. M.; Basit, Abdul W.; Gaisford, Simon (2014-12-10). "Fused-filament 3D printing (3DP) for fabrication of tablets". International Journal of Pharmaceutics. 476 (1): 88–92. doi:10.1016/j.ijpharm.2014.09.044. ISSN   0378-5173. PMID   25275937.
  12. ↑ Goyanes, Alvaro; Robles Martinez, Pamela; Buanz, Asma; Basit, Abdul W.; Gaisford, Simon (2015-10-30). "Effect of geometry on drug release from 3D printed tablets". International Journal of Pharmaceutics. 494 (2): 657–663. doi:10.1016/j.ijpharm.2015.04.069. ISSN   0378-5173. PMID   25934428.
  13. ↑ International Journal of Pharmaceutics Editorial Board.
  14. ↑ "Abdul Basit". scholar.google.com. Retrieved 2021-04-27.
  15. ↑ Davies, Sam (2017-12-04). "FabRx launches Kickstarter campaign as it looks to 3D print medicine for children". TCT Magazine. Retrieved 2020-01-07.
  16. ↑ "FabRx Awarded Innovate UK Grant to Design the World's First Personalised Medicine 3D Printer". FabRx. 2019-04-14. Retrieved 2020-01-07.
  17. ↑ UCL (2019-03-07). "Intract awarded Innovate UK grant to make oral antibody formulation using Soteria® technology". UCL School of Pharmacy. Retrieved 2020-01-07.
  18. ↑ "Intract Pharma awarded £1.4m grant to develop antibodies". EPM Magazine. 2018-12-28. Retrieved 2020-01-07.
  19. ↑ UCL (2014-08-21). "Professor Abdul Basit receives Academy of Pharmaceutical Sciences Award". UCL School of Pharmacy. Retrieved 2020-01-07.
  20. ↑ Basit, Abdul; Gaisford, Simon, eds. (2018). 3D Printing of Pharmaceuticals. AAPS Advances in the Pharmaceutical Sciences Series. Springer International Publishing. ISBN   978-3-319-90754-3.
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